Clinical trial · Interventional
Optimal Dosing of Ketamine for Procedural Sedation and Analgesia in Children
NCT02519595CI-TRIAL-00024242completedPhase 4Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
There is a wide variation of published IV ketamine dosing regimens used for procedural sedation in children in the Emergency Department (ED). The purpose of the study was to compare the efficacy, duration of sedation and adverse events between the three commonly administered doses of IV ketamine (1 mg/kg, 1.5 mg/kg and 2 mg/kg) using the traditional administration method of 30-60 second infusion for ED sedation in children.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Moderate, Deep Sedation | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ketamine IV 1.5mg/kg | Drug | — | UNRESOLVED |
| Ketamine IV 1mg/kg | Drug | — | UNRESOLVED |
| Ketamine IV 2mg/kg | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- ketamine IV 1 mg/kg
- description
- Intervention: A blinded dose of 1mg/kg IV ketamine is administered to patients
- interventionNames
- Drug: Ketamine IV 1mg/kg
- type
- EXPERIMENTAL
- label
- Ketamine IV 1.5 mg/kg
- description
- Intervention: A blinded dose of 1.5mg/kg IV ketamine is administered to patients
- interventionNames
- Drug: Ketamine IV 1.5mg/kg
- type
- EXPERIMENTAL
- label
- Ketamine IV 2 mg/kg
- description
- Intervention: A blinded dose of 2 mg/kg IV ketamine is administered to patients
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 3 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Children 3 -18 years of age * Belonging to American Society of Anesthesiologists (ASA) classification 1 or 2 * Receiving IV ketamine for procedural sedation for orthopedic procedures, * Incision and Drainage of skin abscess and laceration repair Exclusion Criteria: * Contraindications to use of Ketamine * Parents or legal guardian not available or declined to provide informed consent * Child declined to provide assent, * Patients that received intramuscular ketamine, * Patient that received benzodiazepines in addition to ketamine * Children weighing \>100 kilogram * Children with developmental disabilities.
References
Publications (0)
Data not yet available
No reference posted for this study.