Clinical trial · Interventional
Accelerated Recovery Pathway for Discharge After Surgery in Patients With Pancreatic Cancer
A Prospective Randomized Controlled Trial Evaluating an Accelerated 5 Day Pathway for Discharge Following Pancreaticoduodenectomy (PD): Whipple Accelerated Recovery Pathway (WARP Trial)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This randomized clinical trial studies accelerated recovery pathway for discharge after surgery in patients with pancreatic cancer. A standardized accelerated recovery pathway may improve outcomes after surgery following complex abdominal operations resulting in a shorter length of stay in patients with pancreatic cancer. It may also help patients to mobilize more quickly and return to the home setting, decrease hospital-acquired infectious complications, and increase potential cost savings. It is not yet known whether an accelerated recovery pathway is better than a standard recovery pathway for discharge following surgery in patients with pancreatic cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Carcinoma | Pancreatic Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Pancreaticoduodenectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Standard 7-Day Pathway
- description
- Patients follow the standard 7-day pathway following pancreaticoduodenectomy
- interventionNames
- Procedure: Pancreaticoduodenectomy
- type
- EXPERIMENTAL
- label
- Accelerated 5-Day Pathway
- description
- Patients follow the Whipple accelerated 5-day pathway following pancreaticoduodenectomy. The accelerated pathway includes more rapidly leaving the ICU setting, early mobilization and enhanced physical therapy, multimodal pain control, dietary modifications, and increased and standardized phone contact by a nurse practitioner during the first week following hospital discharge.
- interventionNames
- Procedure: Pancreaticoduodenectomy
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Pancreaticoduodenectomy 2. Firm gland texture 3. Subjects able to provide informed consent Exclusion Criteria: 1. Preoperative factors: * Congestive heart failure (CHF) * End stage renal disease (ESRD) * Chronic obstructive pulmonary disease (COPD) * Pregnancy * Albumin \< 3 gm/dL * Poor preoperative performance status as defined by: timed get up and go (\< 15 seconds) * Patients cannot be homeless or have substance dependence 2. Intraoperative factors: * Estimated blood loss (EBL) \> 1 liter * Failure to extubate at the conclusion of the case * Operative time \> 8 hours * Need for vascular resection/reconstruction
References
Publications (1)
- DERIVEDLavu H, McCall NS, Winter JM, Burkhart RA, Pucci M, Leiby BE, Yeo TP, Cannaday S, Yeo CJ. Enhancing Patient Outcomes while Containing Costs after Complex Abdominal Operation: A Randomized Controlled Trial of the Whipple Accelerated Recovery Pathway. J Am Coll Surg. 2019 Apr;228(4):415-424. doi: 10.1016/j.jamcollsurg.2018.12.032. Epub 2019 Jan 17. PMID 30660818