Clinical trial · Interventional
Acupuncture for Postoperative Nausea and Vomiting in Patients Undergoing Colorectal Surgery
High-dose Acupuncture for Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Colorectal Surgery: A Randomized Controlled Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background: PONV is one of the prevalent discomforts in the early phase of recovery after surgery. Evidence suggests that the stimulation of the P6 acupuncture point can reduce the occurrence of PONV. What remains unclear is whether a higher dose of acupuncture produces more benefits compared with P6 stimulation alone or whether acupuncture combined with standard antiemetic medication yields better outcomes. Objectives: This study aims to assess the effectiveness, safety, and feasibility of intensive acupuncture treatments combined with standard antiemetic medication as compared with P6 acupoint stimulation combined with standard antiemetic medication or with standard antiemetic medication alone.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Postoperative Nausea and Vomiting | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| High-dose acupuncture with intravenous infusion of ramosetron | Procedure | — | UNRESOLVED |
| Intravenous infusion of ramosetron | Drug | — | UNRESOLVED |
| P6 stimulation with intravenous infusion of ramosetron | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- High-dose acupuncture with intravenous infusion of ramosetron
- description
- Three sessions of acupuncture on the points of Stomach 36 (ST36), Stomach 37 (ST37), Liver 3 (LR3), Large Intestine 11 (LI11), Large Intestine 4 (LI4), Spleen 6 (SP6), Spleen 4 (SP4), Pericardium 6 (PC6), Heart 8 (HT8), and Gall Bladder 41 (GB41) within 48 hours after surgery
- interventionNames
- Procedure: High-dose acupuncture with intravenous infusion of ramosetron
- Device: P6 stimulation with intravenous infusion of ramosetron
- Drug: Intravenous infusion of ramosetron
- type
- ACTIVE_COMPARATOR
- label
- P6 stimulation with intravenous infusion of ramosetron
- description
- P6 stimulation by wearing a study wristband within 48 hours after surgery
- interventionNames
- Device: P6 stimulation with intravenous infusion of ramosetron
- Drug: Intravenous infusion of ramosetron
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients undergoing elective laparoscopic surgery of colorectal cancer resection (right hemicolectomy, left hemicolectomy, anterior resection with primary anastomosis, and low anterior resection with loop ileostomy for fecal diversion) * Patients aged 18 to 80 * American Society of Anesthesiologists Grade 1 to 2 * Written informed consents Exclusion Criteria: * Pregnancy * Inflammatory bowel disease * Comorbidities that may affect outcomes of surgery (e.g., chronic kidney disease, chronic liver disease, cardiopulmonary failure, and diabetes with complications) * Use of emetogenic / antiemetic medication within 24 hours before surgery * Previous history of emetic episodes after administration of antibiotics * Expected use of mechanical ventilation * Cognitive impairment that may affect the patient's ability to complete the outcome assessments * Previous history of stroke * Previous history of sensitive reaction to acupuncture * Patients unable to cooperate with acupuncture treatments * Pacemaker implantation * Previous history of epilepsy * Patients who have received Korean medicine treatments (acupuncture, moxibustion, cupping, or herbal medicine) within 2 weeks * Patients who have participated in other trials within 3 months
References
Publications (1)
- DERIVEDKim KH, Kim DH, Bae JM, Son GM, Kim KH, Hong SP, Yang GY, Kim HY. Acupuncture and PC6 stimulation for the prevention of postoperative nausea and vomiting in patients undergoing elective laparoscopic resection of colorectal cancer: a study protocol for a three-arm randomised pilot trial. BMJ Open. 2017 Jan 4;7(1):e013457. doi: 10.1136/bmjopen-2016-013457. PMID 28052910