A Study of Afatinib in Patients With Advanced Cancer With Changes in the HER Gene

Inclusion Criteria:

* Patients may have had any number of treatment lines in the curative or metastatic setting for their solid tumors.
* Age 18 years or older.
* At least one measurable lesion
* In patients with previous treatment, evidence of progression of cancer, as per the opinion of the investigator must be present
* Eastern Cooperative Oncology Group (ECOG) performance status ≤1
* Adequate organ function
* Willingness to undergo fresh tumor biopsy at certain timepoints
* Recovered from any previous therapy related side effects
* Able to provide written consent

Exclusion Criteria:

* Chemotherapy, biological therapy or investigational agents within 3 weeks prior to the start of study treatment.
* Hormonal treatment within 3 weeks prior to start of study treatment.
* Radiotherapy within 3 weeks prior to randomization with exceptions
* Major surgery within 3 weeks before starting study treatment or scheduled for surgery during the projected course of the study
* Known exposure to any epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER) 2, HER3 or pan-HER inhibitors, such as, but not limited to afatinib or dacomitinib.
* Patients with inability to swallow whole tablets for afatinib are allowed on the study, but diluted tablets must be taken orally.
* Presence of malabsorption problems including, but not exclusively limited to chronic diarrhea and uncontrolled inflammatory bowel disease.
* History or presence of clinically relevant cardiovascular abnormalities such as uncontrolled hypertension, congestive heart failure, unstable angina or poorly controlled arrhythmia as determined by the investigator. Myocardial infarction within 6 months prior to study entry
* Women of child-bearing potential (WOCBP) and men who are able to father a child, unwilling to be abstinent or use adequate contraception prior to study entry, for the duration of study participation and for at least 28 days after treatment has ended.
* Female patients of childbearing potential who are nursing or are pregnant or are not using an acceptable method of birth control, or do not plan to continue using this method throughout the study and/or do not agree to submit to pregnancy testing required by the study.
* Any history of or concomitant condition that, in the opinion of the Investigator, would compromise the patient's ability to comply with the study or interfere with the evaluation of the efficacy and safety of the study drug
* Previous or concomitant malignancies at other sites, with exceptions
* Requiring treatment with any of the prohibited concomitant medications
* Known pre-existing interstitial lung disease
* Any history or presence of poorly controlled gastrointestinal disorders.
* Known active hepatitis B, active hepatitis C infection and/or known HIV carrier.