Clinical trial · Observational
Vestibular Function After Chemoradiotherapy for Nasopharyngeal Carcinoma
NCT02505672CI-TRIAL-00021804unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Nasopharyngeal carcinoma (NPC) is usually treated with chemoradiotherapy. While the effects of this treatment on cochlear function is well characterized, its effect on vestibular function is not well studied. In this study the investigators will study the vestibular function of 50 patients undergoing chemoradiotherapy for NPC both before and after treatment in order to better define its effects. All patients will undergo a validated questionnaire (dizziness handicap index), posturography, audiometry and vestibular-evoked myogenic potentials.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Nasopharyngeal Carcinoma | Nasopharyngeal Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Chemoradiotherapy for nasopharyngeal carcinoma | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Study group
- description
- Patients older than 18 who are planned to undergo chemoradiotherapy for nasopharyngeal carcinoma.
- interventionNames
- Radiation: Chemoradiotherapy for nasopharyngeal carcinoma
Primary outcomes (4)
- measure
- Subjective dizziness and vestibular dysfunction using the dizziness handicap index
- timeFrame
- 6 months after completion of treatment
- measure
- Hearing level using standard audiometry
- timeFrame
- 6 months after completion of treatment
- measure
- Objective vestibular function using posturography
- timeFrame
- 6 months after completion of treatment
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18 years or older. * Biopsy-proven NPC. * About to undergo chemoradiotherapy with intensity-modulated radiotherapy (IMRT). Exclusion Criteria: * Pregnancy. * Prior vestibular dysfunction.
References
Publications (12)
- BACKGROUNDColaco RJ, Betts G, Donne A, Swindell R, Yap BK, Sykes AJ, Slevin NJ, Homer JJ, Lee LW. Nasopharyngeal carcinoma: a retrospective review of demographics, treatment and patient outcome in a single centre. Clin Oncol (R Coll Radiol). 2013 Mar;25(3):171-7. doi: 10.1016/j.clon.2012.10.006. Epub 2013 Jan 18. PMID 23337060
- BACKGROUNDTuan JK, Ha TC, Ong WS, Siow TR, Tham IW, Yap SP, Tan TW, Chua ET, Fong KW, Wee JT. Late toxicities after conventional radiation therapy alone for nasopharyngeal carcinoma. Radiother Oncol. 2012 Sep;104(3):305-11. doi: 10.1016/j.radonc.2011.12.028. Epub 2012 Jan 24. PMID 22280806
- BACKGROUNDZhang L, Chen QY, Liu H, Tang LQ, Mai HQ. Emerging treatment options for nasopharyngeal carcinoma. Drug Des Devel Ther. 2013;7:37-52. doi: 10.2147/DDDT.S30753. Epub 2013 Feb 1. PMID 23403548
- BACKGROUNDWei Y, Zhou T, Zhu J, Zhang Y, Sun M, Ding X, Wang D, Li H, Li B. Long-term outcome of sensorineural hearing loss in nasopharyngeal carcinoma patients: comparison between treatment with radiotherapy alone and chemoradiotherapy. Cell Biochem Biophys. 2014 Jul;69(3):433-7. doi: 10.1007/s12013-014-9814-x. PMID 24510513
- BACKGROUNDLin C, Lin SW, Weng SF, Lin YS. Risk of developing sudden sensorineural hearing loss in patients with nasopharyngeal carcinoma: a population-based cohort study. Head Neck. 2014 Feb;36(2):203-8. doi: 10.1002/hed.23278. Epub 2013 Jun 18. PMID 23780872
- BACKGROUNDTsang RK, Kwong DL, Ho AC, To VS, Ho WK, Wei WI. Long-term hearing results and otological complications of nasopharyngeal carcinoma patients: comparison between treatment with conventional two-dimensional radiotherapy and intensity-modulated radiotherapy. ORL J Otorhinolaryngol Relat Spec. 2012;74(4):228-33. doi: 10.1159/000341096. Epub 2012 Aug 17. PMID 22907195
- BACKGROUNDChao WY, Tseng HZ, Tsai ST. Caloric response and postural control in patients with nasopharyngeal carcinoma after radiotherapy. Clin Otolaryngol Allied Sci. 1998 Oct;23(5):439-41. doi: 10.1046/j.1365-2273.1998.00170.x.