Clinical trial · Interventional
Efficacy of Nebulized Pulmicort Respules in Primary Lung Cancer Patients With COPD
Efficacy of Nebulized Pulmicort Respules on Post Operation Pulmonary Complication During Pulmonary Single Lobectomy Surgery in Primary Lung Cancer Patients With COPD
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To test the hypothesis that nebulized Pulmicort Respules could reduce post operation pulmonary complication incidence in primary lung cancer patients with COPD. Compare post-operation pulmonary complication incidence in two treatment arms among primary lung cancer patients with COPD required single lobectomy from 3days before operation to 7 days after operation.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| COPD | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Post Operative Complication, Pulmonary | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Budesonide | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- nebulized Budesonide 2mg/4mL
- description
- +terbutaline 5mg/2mL,BID+ipratropium 2 puff(40ug)BID
- interventionNames
- Drug: Budesonide
- type
- PLACEBO_COMPARATOR
- label
- nebulized saline 4mL
- description
- +terbutaline 5mg/2mL,BID+ipratropium 2 puff(40ug)BID
Primary outcomes (1)
- measure
- The incidence of post-operation pulmonary complication in two arms among primary lung cancer patients with COPD
- timeFrame
- 10 days
- description
- Definition of post-operation pulmonary complication: 1. Pneumonia/other pulmonary infections, with X-ray evidence, fever and/or WBC\>15,000mL 2. Sputum retention:classified as purulent and the pour ability grade is 1 or 2 3. Acute respiratory failture or chronic respiratory failture 4. Atelectasis 5. Aerothorax:\>30% by X-ray; pulmonary embolism
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. Newly diagnosed or existing COPD defined by GOLD, and FEV1 of\<80% predicted and FEV1/FVC\<70% 2. Diagnosed as primary lung cancer by China guidelines on diagnosis and treatment of primary lung cancer 3. .Consistent with indication of operation of pulmonary single lobectomy surgery by China guidelines on diagnosis and treatment of primary lung cancer 4. General anesthesia and double cavity intubation was used during operation 5. ASA Classification of Anesthesia Risk is in category 1-3 both in baseline 6. age from 40-80 years old 7. Smoking cessation more than two weeks before operation 8. SP O2\>90% before surgery 9. Hemoglobin \> 10g/dl 10. Estimated duration of surgery \< 4 hours 11. 18.5\<BMI \< 28 Exclusion Criteria: 1. Patients who had taken systemic corticosteroids in the preceding 1month before baseline 2. Patients who had pneumonia in the preceding 1month before baseline 3. Patients with a history of recent myocardial infarction, heart failure, tuberculosis 4. Subject with known or suspected human immunodeficiency virus infection
References
Publications (0)
Data not yet available