Clinical trial · Observational
Exploratory Analysis on the Impact of Morbidities on Colorectal Cancer Screening Uptake
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primary aim of this project is to examine the association between having a long-term condition (morbidity) and screening uptake for colorectal cancer. Whilst this project will consider all morbidity and co-morbidities, there will be a particular focus on common mental health disorders, such as depression and anxiety. The secondary aim of this project is to examine other factors that may influence uptake rate. Information on a wide array of potential factors is available for this project. These include demographics (age, gender, ethnicity), socio-economic status (deprivation, education status) and lifestyle (smoking status, drinking patterns, degree of exercise). In addition, any potential moderating effect of these factors on the association between morbidity and screening uptake shall be explored. In summary, the following shall be explored: * Uptake rates by type of mental health disorder. * Uptake rates by chronic physical health problems. * Associations between uptake, morbidity (both physical and mental) and broader health determinants such as demographics, socio-economic status and lifestyle.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exposure to having a long-term condition. | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Screened
- description
- Those who received an adequate screen for colorectal cancer.
- interventionNames
- Other: Exposure to having a long-term condition.
- label
- Not Screened
- description
- Those who received an adequate screen for colorectal cancer.
- interventionNames
- Other: Exposure to having a long-term condition.
Primary outcomes (1)
- measure
- Individual attended colorectal cancer screening
- timeFrame
- The duration for which the individual was eligible for screening (between 1 and 10 years)
- description
- If the individual attended any colorectal cancer screen (irrespective of the number of invitations) - analysed as a binary yes/no indicator per individual using logistic regression.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
- Maximum age
- 69 Years
Show eligibility criteria text
Inclusion Criteria: * Participants in the South Yorkshire Cohort * Eligible for screening in the NHS Bowel Cancer Screening Programme. Exclusion Criteria: * Have not ticked both boxes on the Consent Form (part of the South Yorkshire Cohort questionnaire) for their data to be used
References
Publications (3)
- BACKGROUNDHarrell FE. Regression modeling strategies: with applications to linear models, logistic regression, and survival analysis. Springer; 2001.
- BACKGROUNDCampbell MJ, Julious SA, Altman DG. Estimating sample sizes for binary, ordered categorical, and continuous outcomes in two group comparisons. BMJ. 1995 Oct 28;311(7013):1145-8. doi: 10.1136/bmj.311.7013.1145. PMID 7580713
- DERIVEDKearns B, Chilcott J, Relton C, Whyte S, Woods HB, Nickerson C, Loban A. The association between long-term conditions and uptake of population-based screening for colorectal cancer: results from two English cohort studies. Cancer Manag Res. 2018 Mar 28;10:637-645. doi: 10.2147/CMAR.S153361. eCollection 2018. PMID 29628776