Clinical trial · Observational
Hepatocellular Cancer (HCC) Screening in Zhongshan City
Searching for Early Detection Biomarkers and to Reduce Mortality Rate of Hepatocellular Cancer (HCC) in Zhongshan City
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
All participants in the selected communities will be tested for HBsAg by using serum samples. Among those who are positive for HBsAg, further clinical work-ups including AFP test and ultrasonography for liver exam will be performed. High risk group will be selected according to the definition. HCC diagnosis will be determined according to imaging and/or biopsy result. Repeated check-ups will be performed in 6-months among HBsAg positive group and 3-years among HBsAg negative group. All subjects in the control arm (control communities) will be followed by record linkage to Cancer Register and Population Register.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver Neoplasms | Liver Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Biomarker testing and Ultrasonography | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Screening
- description
- All participants will be tested for HBsAg by using serum samples. Among those who are positive for HBsAg, further clinical work-ups including AFP test and ultrasonography for liver exam will be performed. Repeated check-ups will be performed in 6-months among HBsAg positive group and 3-years among HBsAg negative group.
- interventionNames
- Biological: Biomarker testing and Ultrasonography
- label
- Non-screening
- description
- All subjects in this arm will be followed by linkage to Cancer Register and Population Register.
Primary outcomes (1)
- measure
- 5-year HCC specific mortality rate
- timeFrame
- 10 years
- description
- To reduce 5-year HCC specific mortality rate compare with that of general population
Secondary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 35 Years
- Maximum age
- 64 Years
Show eligibility criteria text
Inclusion Criteria: * Residences in Zhongshan City * Have no medical records of hepatocellular cancer * ECOG 0-2 * Provide written informed consent forms * Have a good physical and psychological condition Exclusion Criteria: * Have severe cardiovascular or kidney disease * Have medical records of hepatocellular cancer
References
Publications (0)
Data not yet available