Ultrasound Therapy and Therapeutic Exercise for Chemotherapy Induced Peripheral Neuropathy (CIPN)

Inclusion Criteria:

1. adults18 or older,
2. receiving or have received chemotherapy treatment for colon or colorectal cancer,
3. chemotherapy regimen includes the agent oxaliplatin,
4. Grade 1, 2 or 3 on the National Cancer Institute Common Terminology Criteria for Adverse Events for sensory and motor neuropathy.

Exclusion Criteria:

1. neuropathy pre-existing the patient's cancer diagnosis;
2. contraindications to therapeutic ultrasound:

   * active cancer in region of hands or feet,
   * presence of deep vein thrombosis,
   * lack of sensation in hands or feet,
   * metal or plastic implants in hands or feet;
3. peripheral vascular disease or other serious existing non-malignant disease which may affect their ability to complete testing and treatment sessions.