Clinical trial · Observational
Esophageal Atresia: Metaplasia, Barrett
Prevalence of Barrett's Esophagus in Adolescents and Young Adults With Esophageal Atresia
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The frequency of Barrett's esophagus (BE) has increased in adults in the last decades, but BE is rare in children. Esophageal atresia (EA), the most common congenital anomaly affecting the esophagus, predisposes the patient to severe and prolonged gastroesophageal reflux disease. Because gastroesophageal reflux disease plays a major role in the development of BE by causing repeated mucosal damage, development of BE is a concern even in children and young adults in this specific population. The aim of this study is to assess the prevalence of BE (gastric and/or intestinal metaplasia) in a population of adolescents/young adults who had been treated for EA in early infancy. All eligible patients received upper gastrointestinal endoscopy under general anesthesia with standardized esophageal staged biopsies. Histological suspicion of metaplasia was confirmed centrally.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophagus, Barrett | — | UNRESOLVED | — |
| Gastroesophageal Reflux | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| esophageal biopsies | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- single group-study
- interventionNames
- Procedure: esophageal biopsies
Primary outcomes (1)
- measure
- presence of gastric and / or intestinal metaplasia diagnosed at histology
- timeFrame
- during 2 hours of the endoscopy exam
- description
- Prevalence of Barrett's esophagus (gastric and/or intestinal metaplasia) in adolescents treated for esophageal atresia
Secondary outcomes (4)
- measure
- presence of esophagitis or anomalies at the anastomotic stage diagnosed at histology
- timeFrame
- during 2 hours of the endoscopy exam
- measure
- evaluation of the nutritional status
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 15 Years
- Maximum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: * Medical history of esophageal atresia (all types, Ladd's classification) Exclusion Criteria: * No medical history of esophageal atresia * Non acceptance to participate from the patient and/or his parents * esophageal atresia treated with esophageal replacement (e.g., coloplasty, gastric transposition)
References
Publications (1)
- DERIVEDSchneider A, Gottrand F, Bellaiche M, Becmeur F, Lachaux A, Bridoux-Henno L, Michel JL, Faure C, Philippe P, Vandenplas Y, Dupont C, Breton A, Gaudin J, Lamireau T, Muyshont L, Podevin G, Viola S, Bertrand V, Caldari D, Colinet S, Wanty C, Sauleau E, Leteurtre E, Michaud L. Prevalence of Barrett Esophagus in Adolescents and Young Adults With Esophageal Atresia. Ann Surg. 2016 Dec;264(6):1004-1008. doi: 10.1097/SLA.0000000000001540. PMID 26720426