Clinical trial · Interventional
Degradation of the Anorexic Hormone Peptide YY
NCT02493959CI-TRIAL-00018504completedEarly Phase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Peptide YY (PYY) is a gastrointestinal hormone released from the enteroendocrine cell upon food intake. The N-terminal truncated form, PYY3-36, exerts anorexic effects. In this study we want to investigate the kinetics of PYY1-36 and PYY3-36 and to examine whether a C-terminally degraded metabolite, PYY3-34, is formed after infusion of PYY.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Healthy | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| placebo | Biological | — | UNRESOLVED |
| PYY1-36 infusion | Biological | — | UNRESOLVED |
| PYY1-36 + sitagliptin | Biological | — | UNRESOLVED |
| PYY3-36 infusion | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- PYY infusion
- description
- IV infusion on 4 separate days of PYY or saline in Healthy, normal-weight men, age 18-50 years
- interventionNames
- Biological: PYY1-36 infusion
- Biological: PYY1-36 + sitagliptin
- Biological: PYY3-36 infusion
- Biological: placebo
Primary outcomes (2)
- measure
- PYY3-34 concentration
- timeFrame
- 0-240 min
- measure
- Half-lives of PYY1-36 and PYY3-36
- timeFrame
- 0-240 min
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Healthy * Normal BMI (18.5-25kg/m2) Exclusion Criteria: * Diabetes Mellitus * Gastric bypass * Non-caucasian * Height changes \>3 kg within last two months * Hemoglobin \< 7.6 mmol/l * Chronic disease * Smoking * Regularly use of medicine * Drug abuse
References
Publications (0)
Data not yet available
No reference posted for this study.