Clinical trial · Interventional
CIK in Treating Patients With Bladder Cancer
A Randomized Controlled Study of Cytokine-induced Killer Cells (CIK) Treatment in Patients With Staging Ⅰ-Ⅲ of Urinary Bladder Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Chemotherapy is the main treatment method for patients with Bladder Cancer. However, Relapse remains the major cause of treatment failure.Biological therapies such as CIK stimulate the immune system and stop tumor cells from growing. A series of studies reported that cytokine-induced killer cells (CIK) have a broad anti-tumor spectrum. The investigators suppose that CIK will improve the prognosis. Combining chemotherapy with biological therapy may kill more tumor cells. In this study, the patients will be treated with CIK cells after chemotherapy. The purpose of this study is to evaluate the efficacy of CIK for Bladder Cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Urinary Bladder Neoplasms | Bladder Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cytokine-induced Killer Cells | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Non-CIK
- description
- After accepting chemotherapy, patients will regularly follow up.
- type
- EXPERIMENTAL
- label
- CIK
- description
- After accepting chemotherapy, patients will receive at least 3 cycles of Cytokine-induced Killer Cells treatment per year.
- interventionNames
- Biological: Cytokine-induced Killer Cells
Primary outcomes (1)
- measure
- progression-free survival(PFS)
- timeFrame
- 1 month
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients histologically confirmed carcinoma in of the bladder with urinary cytology; * Patients with staging I-III of Bladder Cancer; * Patients who had completed chemotherapy; * Patients who have a life expectancy of at least 12 weeks; * Eastern Cooperative Oncology Group (ECOG) performance status was 0-1; * The bone marrow functioned normally (WBC\>4.0×10\^9/L, Hb\>120 g/L, Platelet(PLT)\>100×10\^9/L); * The ECG results were normal, and the liver and kidney were functional. Exclusion Criteria: * Patients who had upper urinary tract disease (e.g., vesico-ureteral reflux or massive stones) that would make multiple transurethral procedures risk; * Patients who had urethral strictures that would prevent endoscopic procedures and repeated catheterization; * Patients who had prior or concurrent upper urinary tract tumors; * Patients who had distant metastases by imaging studies; * Patients with uncontrolled infection; underlying disease that was severe or life-threatening; * Patients who were lactating; * ECOG perform status ≥ 2; * Patients who are suffering from auto immune diseases or patients who need to accept glucocorticoid treatment; * Patients who are pregnant or nursing; * Patients with active tuberculosis (highly positive skin tests allowed if no active disease); * Patients with disease that would preclude general anesthesia; * Patients with active intractable or uncontrollable infection.
References
Publications (0)
Data not yet available