Clinical trial · Observational
Genetical, Anthropometrical and Biochemical Factors Influencing High Risk Subclinical Atherosclerosis
Subclinical Atherosclerosis: Biomarkers of Early Disease
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Subclinical atherosclerosis is the atherosclerotic process identified before clinical symptoms and thus it can be a useful marker of future cardiovascular events. It can be evaluated by many methods. This study included the diagnosis of subclincal atherosclerosis by four different methods: coronary calcium score, carotid doppler ultrasound to quantify intima media thickness and carotid plaques, exercise stress test and ankle brachial index. Clinical data, anthropometric measures (body mass index, abdominal circumference), markers of inflammation (high sensitive - C reactive protein, TNF alfa and Lipoprotein Associated Phospholipase A2), fat tissue function (leptin, resistin and adiponectin), glucose metabolism (fasting plasma glucose, glycated hemoglobin and insulin) and genetics markers of atherosclerotic process were evaluated as biomarkers of subclinical atherosclerosis in a uneventful population.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Primary Prevention | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Carotid intima-media thickness (cIMT)
- timeFrame
- Four Weeks
- description
- Subclinical atherosclerosis evaluation by quantifying intima media thickness by Doppler
Secondary outcomes (5)
- measure
- Coronary artery calcium score
- timeFrame
- Four weeks
- description
- Subclinical atherosclerosis evaluation by Coronary Artery Calcium by CT
- measure
- Brachial Ankle Index
- timeFrame
- Four weeks
- description
- Subclinical atherosclerosis evaluation by brachial ankle index (BAI) by blood pressure measurement
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 25 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Individuals free of clinical manifested arterial atherosclerotic disease Exclusion Criteria: * Uncontrolled hypothyroidism * Use of hypoglycemic medications * Liver failure * Chronic kidney disease stage IV or V * Heart failure NYHA stage III or IV * HIV positive patients * Withdrawal of informed consent
References
Publications (0)
Data not yet available