Clinical trial · Observational
Hepatic RFA Increases T Cell Infiltraion and PD-L1 Expression in Primary Colorecatl Cancer
Hepatic Radiofrequency Ablation Increases T Cell Infiltraion and PD-L1 Expression in Primary Tumor in Patients With Synchronous Colorectal Cancer Liver Metastases
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
It has been shown that RFA induced systemic tumor antigen-specific T cell responses in human carcinoma. However, there are insufficient studies on the immune modulation of tumor microenviroment (TME) outside of the ablation zone. In order to study how RFA modifies TME in human cancer patients, investigators performed a retrospective study of a unique cohort of patients who suffered from synchronous CRCLM.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hepatic RFA | Procedure | — | UNRESOLVED |
| Primary tumor resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- RFA group
- description
- patients who received hepatic RFA followed by primary tumor resection were assigned to the RFA group
- interventionNames
- Procedure: Hepatic RFA
- Procedure: Primary tumor resection
- label
- Non-RFA group
- description
- patients who received initial primary tumor resection without RFA
- interventionNames
- Procedure: Primary tumor resection
Primary outcomes (2)
- measure
- Number of T cell infiltraion in primary tumor
- timeFrame
- 2 weeks
- description
- Number of T cell infiltraion in primary tumor was evaluated by immunohistochemical staining
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 32 Years
- Maximum age
- 78 Years
Show eligibility criteria text
Inclusion Criteria: Patients with histologically confirmed asynchronous liver metastases received initial hepatic RFA or initial primary tumor resection. Exclusion Criteria: 1. Preoperative CT, RT and other antitumor treatment 2. Emergency surgery 3. Initial hepatectomy 4. No qualified endoscopic biopsy
References
Publications (0)
Data not yet available