Clinical trial · Interventional
EXercise Influence on Taxane Side Effects (EXIT) Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is a randomized control cross over trial of exercise training during or after taxane-containing chemotherapy treatment for breast cancer. Forty-three women with stage I-III breast cancer will be randomized to immediate or delayed thrice weekly exercise training for 8-12 weeks. The immediate exercise group will exercise during taxane chemotherapy and the delayed group will start exercise 2 weeks after completion of treatment. This design will allow for an assessment of the effects of exercise vs usual care during treatment, plus a comparison of the training response during vs. after chemotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Neoplasms | Breast Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Immediate exercise arm
- description
- The length of the intervention for the immediate exercise group will be determined by treatment protocol and could range from 8 to 13 weeks. The intervention can begin up to one week before the first treatment and will continue until 2 weeks after the final taxane-containing treatment. The intervention will consist of thrice weekly supervised aerobic and resistance exercise training.
- interventionNames
- Other: Exercise
- type
- EXPERIMENTAL
- label
- delayed exercise arm
- description
- The delayed exercise group will begin an exercise intervention two weeks after completion of their last taxane-containing chemotherapy treatment that will last the length of their taxane chemotherapy plus two weeks. If participants in the delayed exercise group have a surgery planned during the intervention time that will require \>1 week off from exercise, the exercise intervention will be delayed until after the surgery. The intervention will consist of thrice weekly supervised aerobic and resistance exercise training.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: * Born female * Age 19 or older * Histologically confirmed stage I-IIIA breast cancer diagnosis * Scheduled to receive neoadjuvant or adjuvant taxane-containing chemotherapy * Willing and able to attend baseline assessment prior to first taxane-containing treatment * Have reliable transportation to attend our exercise gym located near the Vancouver BCCA three times weekly for 8-13 weeks * Be able to read and communicate in English * Treating medical oncologist approval to participate Exclusion Criteria: * Receipt of further chemotherapy treatments after taxane-containing treatments * Stage IV cancer * Acute or uncontrolled health conditions including heart disease, respiratory disease (COPD or severe asthma) * Diagnosis of diabetes at any time * Personal history of neurological disorder * Mobility issues that require a mobility aid or that prevent exercise on a bike, treadmill, or elliptical (includes orthopedic injury or arthritis that result in inability to exercise) * Body mass index ≥40 kg/m2 * Previously received chemotherapy or thoracic radiation treatment
References
Publications (0)
Data not yet available