Clinical trial · Interventional
Preventive Strategies in Colorectal Carcinogenesis Production and Meat Processing
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Colorectal Cancer is, in non-smokers for both sex, first cause of cancers mortality in Western country. The main risk factors associated with colorectal cancer depend of lifestyle, and processed meat and red meat could be involved in carcinogenesis by cytotoxic and genotoxic compound linked to lipid peroxidation and nitrosation. The aim of this study is to study the impact of the daily consumption of beef, processed or not, on lipid peroxidation induced heme iron ; and to study the impact of the daily consumption of ham, processed or not, on the nitrosilation induced heme iron.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ham | Other | — | UNRESOLVED |
| ham + pomegranate extract | Other | — | UNRESOLVED |
| ham + tocopherol | Other | — | UNRESOLVED |
| marinated cooked sirloin steak | Other | — | UNRESOLVED |
| marinated rare sirloin steak | Other | — | UNRESOLVED |
| rare sirloin steak | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (6)
- type
- PLACEBO_COMPARATOR
- label
- ham
- description
- 160g per day during 4 days
- interventionNames
- Other: ham
- type
- EXPERIMENTAL
- label
- ham + pomegranate extract
- description
- 160g per day during 4 days
- interventionNames
- Other: ham + pomegranate extract
- type
- EXPERIMENTAL
- label
- ham + tocopherol
- description
- 160g per day during 4 days
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 40 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Male * Body mass index 20 \<= BMI \<= 30 kg/m2 * Affiliated to French National Health Insurance * Subject giving his written informed consent * Subject considered as normal after clinical examination and medical questionnaire Exclusion Criteria: * Previous medical and/or surgery judged by the investigator as incompatible with this study * Previous familial of colon, ovarian or breast cancer * Chronic pathologies : cardiovascular diseases, cancer, chronic inflammation diseases, renal, intestinal impairments * Dislike ham or red meat * Heavy consumer of alcohol * Practising intensive physical exercise (\> 5 hours) * Being under someone's supervision * Refusal to be registered on the National Volunteers Data file * Dietary habits unreliable to controlled food intake * Being in exclusion on the National Volunteers Data file
References
Publications (0)
Data not yet available