Clinical trial · Interventional
The Role of the Vitamin D Receptor Gene Polymorphisms in Hepatocarcinogenesis
The Role of the Vitamin D Receptor Gene Polymorphisms in Hepatocarcinogenesis in Cirrhotic Patients Infected With Chronic Hepatitis C Virus
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Previous data have suggested that vitamin D levels may influence cancer development. In particular, several single nucleotide polymorphisms have been described in the Vitamin D receptor( VDR gene), and some polymorphisms are associated with tumor occurrence. For instance, VDR polymorphisms have been related to cancers of the breast, prostate, skin, colon-rectum, bladder and kidney, although with conflicting observations . VDR polymorphisms have also been investigated in the context of some chronic liver diseases, such as chronic hepatitis B, primary biliary cirrhosis and autoimmune hepatitis . In a recent published study, VDR polymorphism may be used as a molecular marker to predict the risk and to evaluate the disease severity of HCC in patients with chronic hepatitis B. A significant association of VDR (ApaI) polymorphism with the development of HCC in chronic HCV infection may help to identify those who are at high risk of developing HCC.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver Cancer | Malignant Liver Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| The VDR genotype | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- OTHER
- label
- Hepatocellular carcinoma (HCC)
- description
- The VDR genotype in 20 HCV cirrhotic patient with HCC
- interventionNames
- Other: The VDR genotype
- type
- OTHER
- label
- Liver cirrhosis
- description
- The VDR genotype in 20 HCV cirrhotic patient without HCC
- interventionNames
- Other: The VDR genotype
- type
- OTHER
- label
- Control group
- description
- The The VDR genotype in 10 healthy individuals as control
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Hcv cirrhotic patient with and without Hcc Exclusion Criteria: * Malignancy other than HCC * Co-infection with Hepatitis B virus (HBV) and Human immunodeficiency virus (HIV) * Cirrhosis is due to causes other than chronic hepatitis C
References
Publications (0)
Data not yet available