Clinical trial · Interventional
Synergistic Effect of Ibuprofen and Hydromorphone for Postoperative Pain
NCT02461056CI-TRIAL-00018122completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Intravenous form of ibuprofen is recently approved by FDA and reports are rare on the co-administration with opioids. The investigators searched whether intravenous ibuprofen-hydromorphone combination is synergistic, additive, or infra-additive on postoperative pain using combination index (CI), dose reduction index (DRI) and isobologram.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hydromorphone | Drug | — | UNRESOLVED |
| Ibuprofen | Drug | Ibuprofen | ALIAS |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Ibuprofen
- description
- Ibuprofen: Patients receive ibuprofen 50 mg, 100 mg, 200 mg, 400mg or 800 mg intravenously once at post-anesthesia care unit.
- interventionNames
- Drug: Ibuprofen
- type
- ACTIVE_COMPARATOR
- label
- hydromorphone
- description
- Hydromorphone: Patients receive hydromorphone 0.25 mg, 0.5 mg, 1 mg, 1.5 mg, or 2 mg intravenously once at post-anesthesia care unit.
- interventionNames
- Drug: Hydromorphone
- type
- ACTIVE_COMPARATOR
- label
- ibuprofen+hydromorphone
- description
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 19 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status І or ІІ who were able to communicate and understand the pain scales Exclusion Criteria: * any contraindication to the use of ibuprofen or hydromorphone * a history of allergy or hypersensitivity * a calculated creatinine clearance of \<75 mL/min * the presence or history of asthma, bleeding tendency, coronary artery bypass graft (CABG) surgery, heart failure, peptic ulcer disease, inflammatory bowel disease or any other gastrointestinal disorder, and renal or hepatic disease * pregnancy * age younger than 18 yr * intraoperative use of regional anesthesia * intraoperative administration of analgesics other than remifentanil * postoperative pain ≤3 on a NRS in the post-anesthesia care unit (PACU)
References
Publications (0)
Data not yet available
No reference posted for this study.