Clinical trial · Interventional
Intraoperational Prostate Loge Biopsies (iPROLOGX) After Radical Prostatovesiculectomy
Intraoperational Prostate Loge Biopsies (iPROLOGX) After Radical Prostatovesiculectomy (RPVE) in Prostate Cancer (PCA) Patients for Molecular Tumor Marker Analysis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This project is about the detection of occult tumor cells in surgical margins of radical prostatovesiculectomy by analysing the methylation status of Glutathione S-transferase P 1 (GSTP1). After gland excision specimens are obtained from 9 defined areas of the prostatic fossa. The biopsies are divided into two parts. One part used for histopathological analysis and the other part for moleculargenetic analysis. Results will be correlated e.g. with tumor stage, Gleason Score and prostate specific antigen (PSA). The prostate-cancer-negative control group with bladder cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| biopsies of the prostatic fossa in gronau | Procedure | — | UNRESOLVED |
| biopsies of the prostatic fossa in Magdeburg | Procedure | — | UNRESOLVED |
| CE | Procedure | — | UNRESOLVED |
| ETRARP | Procedure | — | UNRESOLVED |
| RPVE | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- PCA Magdeburg
- description
- Prostate cancer conducted for RPVE with curative Intention, biopsies of the prostatic fossa in Magdeburg
- interventionNames
- Procedure: biopsies of the prostatic fossa in Magdeburg
- Procedure: RPVE
- type
- ACTIVE_COMPARATOR
- label
- Non-prostate cancer Magdeburg/Gronau
- description
- Conducted for CE in Male with bladder cancer or other indication for cystectomy but without prostate cancer in Magdeburg or Gronau, biopsies of the prostatic fossa in Gronau
- interventionNames
- Procedure: biopsies of the prostatic fossa in Magdeburg
- Procedure: CE
- Procedure: biopsies of the prostatic fossa in gronau
- type
Eligibility
Eligibility (as posted)
- Sex
- Male
Show eligibility criteria text
Criteria for patients with prostate adenocarcinoma: Inclusion Criteria * sex: male * diagnosis: prostate adenocarcinoma * treatment: radical prostatovesiculectomy * period of treatment: 11/30/2011 - 10/15/2013 Exclusion Criteria * sex: female * diagnosis: no prostate adenocarcinoma * treatment: no radical prostatovesiculectomy * period of treament: before 11/30/2011 or after 10/15/2013 Criteria for prostate adenocarcinoma negative control group: Inclusion Criteria * sex: male * diagnosis: urothelial carcinoma * treatment: cysto-prostatectomy * period of treament: 12/14/2011 - 02/18/2014 Exclusion Criteria * sex: female * diagnosis: incidental prostate adenocarcinoma * treatment: no cysto-prostatectomy * period of treatment: before 12/14/2011 or after 02/18/2014
References
Publications (0)
Data not yet available