Clinical trial · Interventional
Palliative Radiotherapy Protocol in Head and Neck Cancer
Palliative Radiotherapy for Advanced Head and Neck Carcinomas, a Phase II Study
NCT02460471CI-TRIAL-00018099completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Phase II prospective study or Palliative Radiotherapy of 25 Gy in 5 fractions, Intensity Modulated, for frail patients with incurable head and neck cancer. Comprehensive Quality of life (QLQ-C30, head and neck module, QLQ C15 PAL) and toxicity data (CTCAE v 4.0) collected.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Neoplasms | Head and Neck Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Quality of Life | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| palliative radiation therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- palliative radiation therapy
- description
- 25 Gy in 5 daily fractions
- interventionNames
- Radiation: palliative radiation therapy
Primary outcomes (1)
- measure
- Quality of life
- timeFrame
- from radiation treatment until 24 months planned follow-up or death
- description
- EORTC QLQ-C30 questionnaire (QLQ-C15-PAL and H\&N35 modules)
Secondary outcomes (1)
- measure
- Toxicity (CTCAE v 4.0 graded)
- timeFrame
- from radiation treatment until 24 months planned follow-up or death
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Able to give an informed consent * Able to complete QOL questionnaires * Deemed incurable by an experienced tumour board or unwilling to receive a radical course of radiation therapy * Presence of measurable disease * Biopsy proven squamous or salivary cancer of the head and neck region * Expected survival of at least 2 months. Exclusion Criteria: * Pregnancy * No previous RT to the neck and no plan to receive concomitant chemotherapy * Special histology (Lymphoma, small cell cancer, metastasis from a site other than the head and neck region) * Unavailable for follow-up
References
Publications (1)
- DERIVEDFortin B, Khaouam N, Filion E, Nguyen-Tan PF, Bujold A, Lambert L. Palliative Radiation Therapy for Advanced Head and Neck Carcinomas: A Phase 2 Study. Int J Radiat Oncol Biol Phys. 2016 Jun 1;95(2):647-53. doi: 10.1016/j.ijrobp.2016.01.039. Epub 2016 Jan 28. PMID 27020111