Functional Outcomes Following Hip Core Decompression in Younger Participants With Osteonecrosis

Although uncommon in the general pediatric population, osteonecrosis (ON) is prevalent in children and adolescents with cancer, particularly among those that have had chronic exposure to glucocorticoids and among those having undergone allogeneic hematopoietic stem cell transplantation. Patients with hematologic disease are also at risk for developing ON. Hip Core Decompression (HCD) is a widely used surgical procedure with several studies reporting positive results; however, most are subject to criticism because of the limited sample size or the absence of appropriate functional outcome measures. The objective of this pilot study is to observe and collect information on several functional outcome measures and assess if Hip Core Decompression (HCD) potentially improves functional outcomes in children, adolescents and young adults with osteonecrosis. PRIMARY OBJECTIVE: * To describe functional outcomes of children, adolescents, and young adults with osteonecrosis of the femoral head following hip core decompression surgery. Parameters assessed will include pain, functional mobility, endurance, quality of life, and gait patterns pre-operatively and post-operatively over time.

Sex

All

Minimum age

8 Years

Maximum age

29 Years

Inclusion Criteria:

* Patient being treated at St. Jude Children's Research Hospital
* Diagnosis of osteonecrosis of the hip
* Diagnosis of hematologic malignancy or sickle cell disease
* Age between 8 and 29 years of age
* Patient and/or parent or legal guardian must sign a written informed consent
* Patient is considered an acceptable candidate for hip core decompression surgery by his/her primary physician and orthopedic surgeon

Exclusion Criteria:

* Patient with a diagnosis that is not a hematologic malignancy or sickle cell disease
* Patient that has had amputation or reconstructive surgery of the lower extremities
* Premorbid condition that prevents patient from ambulating
* Patient that has a serious, non-healing wound, ulcer, or bone fracture