Clinical trial · Observational
Assessing the Effect of Contact Isolation on Nosocomial Colonization With ESBL-EC in German Hematology/Oncology Wards
A Hospital-based Cohort Study in German Hematological / Oncological Wards to Assess the Effect of Contact Isolation on Nosocomial Colonization With ESBL-producing Escherichia Coli (CONTAIN Study)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to evaluate the impact of contact isolation on the rate of hospital-acquired transmissions of ESBL-producing Escherichia coli (ESBL-EC) and the rate of colonization and infection. On the basis of this study, it will be possible to re-evaluate the need for contact isolation for patients colonized or infected with ESBL-EC.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hematological Disease | — | UNRESOLVED | — |
| Infection Due to ESBL Escherichia Coli | — | UNRESOLVED | — |
| Oncology [See Also, Affected System] | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Centers using contact isolation
- description
- * Isolation triggered by the detection of ESBL-EC at hospital admission in surveillance screening or during the hospitalization by weekly screening or clinical cultures * Contact isolation terminated, after at least two negative consecutive fecal screening cultures * Contact isolation resumed, if subsequent ESBL-EC positive cultures are identified for the same patient including readmissions Contact isolation must include: * Patient placement in single rooms * Cohorting only possible, when no single rooms available and corresponding ESBL-EC strains are phenotypically identical * Staff and visitors wearing gloves and gowns as contact precautions when entering the room, patient when leaving the room
- label
- Centers using no contact isolation
- description
- * not regularly isolating for ESBL-EC * ESBL-EC colonized or infected patients with urinary or fecal incontinence or diarrhea (\>3 loose bowel movements/day) isolated in single rooms with above described contact precautions
Primary outcomes (1)
- measure
- Incidence of hospital-acquired ESBL-EC colonization or infection
- timeFrame
- up to 12 month
Secondary outcomes (7)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Wards adhering to at least the following standard of care are eligible for study participation: * Fecal screening for the presence of ESBL-EC of all patients within 72 hours of each admission by use of a rectal swab or stool sample * Follow-up fecal screening once a week and within 72 hours of discharge Exclusion Criteria: * none
References
Publications (0)
Data not yet available