Clinical trial · Interventional
Intrathecal Ketamine, Dexmedetomidine and Both With Bupivacaine for Postoperative Abdominal Cancer Surgery Pain
Intrathecally Administered Ketamine, Dexmedetomidine, and Their Combination With Bupivacaine for Postoperative Analgesia in Major Abdominal Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Currently, opioids are widely used for pain relief, but they often provide sub-optimal analgesia with occasional serious side effects. Preservative-free ketamine hydrochloride was introduced as a spinal anesthetic more than twenty years ago and found to have advantages over local anesthetics. Intrathecal dexmedetomidine provides an analgesic effect in postoperative pain without severe sedation. The objectives of this study were to compare the efficacy and safety of intrathecally administered dexmedetomidine, ketamine, or their combination when added to bupivacaine for postoperative analgesia in major abdominal cancer surgery.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pain Management | — | UNRESOLVED | — |
| Therapy | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bupivacaine | Drug | — | UNRESOLVED |
| Dexmedetomidine | Drug | — | UNRESOLVED |
| intrathecal drug administration | Procedure | — | UNRESOLVED |
| ketamine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- dexmedetomidine (I)
- description
- intrathecal drug administartion of 10 mg of hyperbaric bupivacaine 0.5% in 2 ml volume and 5µg of dexmedetomidine in 1 ml volume.
- interventionNames
- Procedure: intrathecal drug administration
- Drug: Dexmedetomidine
- Drug: Bupivacaine
- type
- ACTIVE_COMPARATOR
- label
- ketamine (II)
- description
- intrathecal drug administartion of 10 mg of hyperbaric bupivacaine 0.5% in 2 ml volume and 0.1 mg/kg ketamine in 1ml volume.
- interventionNames
- Procedure: intrathecal drug administration
- Drug: ketamine
- Drug: Bupivacaine
- type
- ACTIVE_COMPARATOR
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 30 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Aged 30-50 years * American Society of Anesthesia (ASA) I-II patients * scheduled for major abdominal cancer surgery Exclusion Criteria: * known allergy to the study drugs. * significant cardiac, respiratory, renal or hepatic disease * coagulation disorder * infection at the site of intrathecal injection * drug or alcohol abuse * BMI \> 30 kg/m2 * psychiatric illnesses that would interfere with perception and assessment of pain
References
Publications (0)
Data not yet available