Recombinant Anti-tumor and Anti-virus Protein for Injection to Treat Advanced Neuroendocrine Tumors

Inclusion Criteria:

* Have been fully aware of the study and voluntarily signed the informed consent.
* At least 18 years old.
* Have a confirmed histological or cytological diagnosis of low- or intermediate-grade advanced NETs (unresectable or metastatic), the pathology must meet one of the following criteria: (a) primary site of lung or thymus (carcinoid) with mitotic count of ≤ 10/10 High Power Field \[HPF\]) (b) other primary site (including primary unknown) with mitotic count of ≤ 20/10 High Power Field \[HPF\] and Ki67 index of ≤ 20%，or with Ki67 index of \> 20% and well-differentiated.
* Patients who have failed standard treatment or are unable to receive standard treatment, and have disease progression within the past 12 months;
* At least one measurable lesion according to the RECIST 1.1 criteria that has not been previously locally treated.
* ECOG performance status 0, 1 or 2.
* Minimum of 4 weeks since any local radiotherapy or surgery for the control of symptoms or severe complications(local radiotherapy for the control of bone metastases is not the limit)，and adequately recovered from toxicities of any prior therapy).
* Life expectancy of at least 3 months.

Exclusion Criteria:

* Prior treatment with Recombinant Anti-tumor and Anti-virus Protein for Injection.
* Prior treatment with Interferon.
* Pregnancy or breast-feeding women or women who may be pregnant were positive drug test before administration.
* Patient of child-bearing potential(male or less than 1 year postmenopausal women) were reluctant to take contraceptive measures.
* Patient who were allergic to Interferon-α or who had interferon-α antibody.
* Have brain metastases or previous history of brain metastases or history of seizures.