Clinical trial · Observational
Timing of Rectal Cancer Resection After Preoperative Chemoradiotherapy
T4RC North: Timing of Rectal Cancer Resection After Preoperative Chemoradiotherapy; Does a Longer Wait Improve Outcomes?
NCT02441153CI-TRIAL-00040137T4RCcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This pilot study will take place at Health Sciences North (HSN) in Sudbury. Patients will be identified and screened for inclusion into the study once referred to a general or colorectal surgeon for resection of their rectal cancer. This may occur before or after preoperative chemoradiotherapy (CRT) but randomization will take place after CRT.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Neoplasms | Rectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Extended Timing | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Group 1(Extended Timing)
- description
- Surgery will be performed at 10-11 weeks after the completion of chemoradiotherapy.
- interventionNames
- Other: Extended Timing
- label
- Group 2 (Non-extended timing)
- description
- Surgery will be performed at 6-7 weeks after completion of chemoradiotherapy.
Primary outcomes (1)
- measure
- Disease-free survival
- timeFrame
- 3 years post surgery
- description
- The absence of any local recurrence or metastatic disease discovered on physical exam, endoscopy, or imaging
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients (\>18 years) * T3/4N0M0 or TxN+M0 rectal cancer below or at the peritoneal reflection, confirmed on clinical exam, histology, pelvic MRI, and CT chest/abdo * Patients who have completed a CRT protocol for the above tumor at HSN * Informed consent given * Surgical resection with TME planned Exclusion Criteria: * Metastatic disease * Failure to complete preoperative CRT * Unable to give free and informed consent * Unable to comply with the requirements of the study * Previous malignancy other than nonmelanoma skin cancer, papillary or follicular thyroid cancer * Inflammatory bowel disease * Hereditary colorectal cancer
References
Publications (0)
Data not yet available
No reference posted for this study.