Clinical trial · Interventional
Continuous Infusion of Ropivacaine Hydrochloride in Reducing Pain After Surgery in Patients With Bladder Cancer
Efficacy of Continuous Infusion of Local Anesthesia After Radical Cystectomy: A Randomized, Double Blind, Placebo Controlled Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): No funding
Summary
Brief summary (as posted)
This randomized phase IV trial studies how well the continuous infusion of ropivacaine hydrochloride works in reducing pain after surgery in patients with bladder cancer. Ropivacaine hydrochloride is an anesthetic drug used to decrease pain by numbing an area of the body without putting the patient to sleep. Continuous infusion of ropivacaine hydrochloride may reduce pain and improve the quality of life for patients after bladder surgery.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bladder Carcinoma | Bladder Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Post-operative Pain | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Placebo | Other | — | UNRESOLVED |
| Questionnaire Administration | Other | — | UNRESOLVED |
| Ropivacaine Hydrochloride | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Arm I (ropivacaine hydrochloride)
- description
- Patients receive ropivacaine hydrochloride IV continuously over 72 hours after radical cystectomy.
- interventionNames
- Other: Questionnaire Administration
- Drug: Ropivacaine Hydrochloride
- type
- PLACEBO_COMPARATOR
- label
- Arm II (placebo)
- description
- Patients receive normal saline (placebo) IV continuously over 72 hours after radical cystectomy.
- interventionNames
- Other: Placebo
- Other: Questionnaire Administration
Primary outcomes (1)
- measure
- Narcotic requirement
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Undergoing elective open radical cystectomy * Ability to understand and the willingness to sign a written informed consent Exclusion Criteria: * Allergy or adverse reaction to ropivacaine (ropivacaine hydrochloride) or any amide type of local anesthesia * Allergy or adverse reaction to local anesthesia catheter * Additional surgery at the same time as RC (e.g. nephroureterectomy) * Coagulopathy * Thrombocytopenia * Local or systemic infection * Pregnancy * Chronic hepatic disease * Use of type III antiarrhythmics (e.g. amiodarone) * History of chronic pain and/or daily opioid use
References
Publications (0)
Data not yet available