Study of Weekly Paclitaxel and Cisplatin in FIGO IB2 and IIA2 Cervical Cancer Followed by Radical Hysterectomy

Inclusion Criteria:

1. Women with previously untreated, histologically confirmed squamous cell carcinoma of the uterine cervix
2. HPV16-positive aged 35-70 years or HPV16-negative age \<55 years
3. FIGO stage IB2 or bulky IIA, with tumor extending to the vagina within the upper one third of the vaginal wall. Bulky tumor is defined as

   1. a visible cervical tumor with the largest diameter \>4 cm or (b) a cervix expanded to \> 4 cm as a result of tumor infiltration by pelvic examination
   2. verified by magnetic resonance image (MRI) or 3-dimensional (D) computed tomography (CT)
4. no suspicious extrapelvic metastasis detected by MRI or 3-D CT
5. adequate marrow, liver and renal functions :hemoglobin level \>= 10 g/dL, WBC count \>= 3,000/mm3 or absolute neutrophil count \>= 1,500/mm3, platelet count \>= 100,000/mm3, serum transaminase (AST, ALT) levels \<= 60 IU/mL, total serum bilirubin within normal range, serum creatinine level \<= 1.5 mg/dL, and blood urea nitrogen level \<=20 mg/dL
6. adequate cardiopulmonary function that tolerates the administration of study regimen and radical hysterectomy
7. Eastern Cooperative Oncology Group performance status of 0 to 1
8. had written informed consent to participate in the study
9. Appropriate organ and marrow function :

   leukocytes \>=3,000/μL absolute neutrophil count \>= 1,500/μL platelets \>= 100,000/μL (not platelet transfusion dependent) hemoglobin \>= 10 g/dL total bilirubin within normal range AST/ALT \<= 2.5 X upper limit of normal range (ULN) BUN \<= 20 mg/dL serum creatinine \<=1.5 mg/dL or clearance \> 60 mL/min
10. a negative urinary pregnancy test in a patient with child-bearing potential

Exclusion Criteria:

Patients will be excluded from the study if they meet any of the following criteria:

1. adenocarcinoma , adenosquamous carcinoma, or small cell carcinoma
2. concurrent or history of malignant tumor(s) other than treated nonmelanoma skin cancer
3. had received surgical procedure other than cervical biopsy or cytotoxic procedure including chemotherapy, radiotherapy or therapy with biologic response modifier(s) for the cervical tumor
4. enlarged pelvic lymph node with positive aspiration cytologic or histologic study
5. participate in investigational treatment or another clinical trial for cervical cancer
6. history of allergic reaction to platinum or paclitaxel
7. uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
8. pregnant or breast feeding women