Clinical trial · Interventional
Light Therapy to Increase Energy in Adolescents and Young Adults Newly Diagnosed With Solid Tumors: A Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Fatigue is one of the most consistent and distressing symptoms reported by pediatric oncology patients. The investigators' work has demonstrated that in the period from diagnosis through the initial 8 weeks of treatment, adolescents and young adults with solid tumors experience substantial fatigue that is not related to sleep disruption. Fatigue can contribute to many adverse outcomes including poor treatment adherence, reduced social activities, depressive symptoms, behavior problems, and poorer quality of life. Unfortunately, no definitive intervention to reduce fatigue has been developed for pediatric oncology patients. Investigators propose a study to estimate the feasibility and acceptability of bright light therapy as an intervention to decrease fatigue in adolescents and young adults who are newly diagnosed and receiving treatment for solid tumors, including lymphoma.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Fatigue | — | UNRESOLVED | — |
| Neoplasms | Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bright White Light | Other | — | UNRESOLVED |
| Dim Red Light | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Bright White Light
- description
- Participants use the bright white light intervention for 30 minutes upon waking each morning for 60 days.
- interventionNames
- Other: Bright White Light
- type
- EXPERIMENTAL
- label
- Dim Red Light
- description
- Participants use the dim red light intervention for 30 minutes upon waking each morning for 60 days.
- interventionNames
- Other: Dim Red Light
Primary outcomes (3)
- measure
- Rate of consent
- timeFrame
- Day 0
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 12 Years
Show eligibility criteria text
INCLUSION CRITERIA: * Age 12 years or older * Has initiated treatment as part of an active St. Jude Children's Research Hospital (SJCRH) treatment plan * ≤ 30 days post diagnosis of a solid tumor or lymphoma * Patient speaks, reads and writes in English or Spanish * Potential participant/guardian is willing to sign informed consent EXCLUSION CRITERIA: * Blind or having a history of eye disease including, but not limited to, macular degeneration, or other diagnosed retinal problems * Undergone laser corrective eye surgery in the past 30 days * Significant physiological or psychological impairment that interferes with participation (e.g., migraines, bipolar disorder, psychosis, seasonal affective disorder) * Recently started on anti-depressant medications (past one month for those on Selective Serotonin Reuptake Inhibitors \[SSRI\] and past two months for those started on Monoamine Oxidase Inhibitors \[MAOI\])
References
Publications (1)
- DERIVEDCrabtree VM, LaRosa KN, MacArthur E, Russell K, Wang F, Zhang H, Pan H, Brigden J, Schwartz LE, Wilson M, Pappo A. Feasibility and Acceptability of Light Therapy to Reduce Fatigue in Adolescents and Young Adults Receiving Cancer-Directed Therapy. Behav Sleep Med. 2021 Jul-Aug;19(4):492-504. doi: 10.1080/15402002.2020.1797744. Epub 2020 Aug 4. PMID 32746639