Clinical trial · Observational
Prognostic Significance of Preoperative Hemoglobin A1c (HbA1c) in Renal Cell Carcinoma
Prospective Cohort Study for the Impact of Preoperative Glycemic Control Status Measured by HbA1c Levels on Pathologic Features and Oncological Outcomes in the Patients With Renal Cell Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The effect of preoperative glycemic control measured by HbA1c on renal cell carcinoma (RCC) outcome remains controversial. Thus, the investigators aim to examine the association of preoperative glycemic control with oncologic outcomes after radical or partial nephrectomy. The investigators will prospectively collect the relevant data including preoperative HbA1c in 238 patients of RCC patients undergoing nephrectomy. The associations between clinical variables and risk of adverse pathological features and disease recurrence will be tested using a multivariate logistic regression and multiple Cox-proportional hazards model, respectively.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoma, Renal Cell | Renal Cell Carcinoma | CURATED_BROADER | 0.80 |
| Hemoglobin A1c Protein, Human | — | UNRESOLVED | — |
| Pathology | — | UNRESOLVED | — |
| Treatment Outcome | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- TMN stage
- timeFrame
- within 2 weeks after surgery
- description
- Pathological outcomes
- measure
- Fuhrman (nuclear) grade
- timeFrame
- within 2 weeks after surgery
- description
- Pathological outcomes
- measure
- Recurrence-free survival
- timeFrame
- postoperative up to 3 years
- description
- Oncological outcome: recurrence-free survival
Secondary outcomes (1)
- measure
- Postoperative renal function as assessed by estimated glomerular filtration rate (GFR)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Renal cell carcinoma (RCC) by image work-up such as CT scan * Clinically localized RCC * Aged over 20 years * Patients undergoing radical or partial nephrectomy Exclusion Criteria: * distant metastasis, preoperatively * preoperative targeted therapy * preoperative immunotherapy * medications affecting glucose status other than diabetes mellitus
References
Publications (0)
Data not yet available