Clinical trial · Observational
Neurotoxic Symptoms in Adjuvant Chemotherapy in Patients With Colorectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Subgroups of patients with radically operated colorectal cancer can have a better prognosis by over six months are treated with chemotherapy. This beneficial effect may be enhanced somewhat by providing a combination of chemotherapy and the addition of oxaliplatin. It is known that this treatment additions increase the risk of neurotoxic side effects such as sensitivity to cold, numbness and tingling in hands or feet, muscle cramps, pain, taste disorders and swallowing difficulties. The aim is to investigate how colorectal cancer patients with oxaliplatin adjuvant chemotherapy experience neurotoxic effects and if the experience of the symptoms change over time during treatment and how symptoms affect patients' daily lives and quality of life.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| oxaliplatin | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Oxaliplatin-Specific Neurotoxicity Scale
- timeFrame
- up to 12 months
Secondary outcomes (2)
- measure
- Health related quality of life (Fact-G) Questionnaire
- timeFrame
- up to 12 months
- measure
- Sense of Coherence scale (SOC-scale)
- timeFrame
- up to 12 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Colorectal cancer patients recieved adjuvant oxaliplatin chemotherapy after radical surgery * Ability to answer questions in swedish language * Ability to answer questions in mobile telephone Exclusion Criteria: * Colorectal cancer patients in other regimes (palliative setting, no surgery) * Non ability to answer questions in swedish language * Non ability to answer questions in mobile telephone
References
Publications (1)
- DERIVEDDrott J, Fomichov V, Borjeson S, Bertero C. Sense of coherence and health-related quality of life in patients with neurotoxicity after cancer chemotherapy: Assessment from a real-time mobile phone-based system. Psychooncology. 2020 Jan;29(1):107-113. doi: 10.1002/pon.5243. Epub 2019 Oct 31. PMID 31670431