Clinical trial · Interventional
Effect of Dexmedetomidine After Thyroidectomy
Effect of Dexmedetomidine Infusion for Postoperative Outcome and Smooth Emergence After Thyroidectomy
NCT02412150CI-TRIAL-00048518completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of the present study was to compare the effect of dexmedetomidine which is administered during emergence in adult patients undergoing elective thyroidectomy on smooth emergence form general anesthesia (reducing agitation or coughing, signs of hypertension or tachycardia, or etc.) and postoperative outcome (postoperative bleeding and hospital staying).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Tumor | Thyroid Gland Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (13)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cough reflex | Behavioral | — | UNRESOLVED |
| Desflurane | Drug | — | UNRESOLVED |
| Dexmedetomidine | Drug | — | UNRESOLVED |
| Extubation time and Recovery time | Other | — | UNRESOLVED |
| Normal saline | Drug | — | UNRESOLVED |
| Postoperative bleeding | Other | — | UNRESOLVED |
| Postoperative complications | Other | — | UNRESOLVED |
| Ramsay Sedation Scale | Behavioral | — | UNRESOLVED |
| Remifentanil | Drug |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Dexmedetomidine (Group D)
- description
- After induction of anesthesia, anesthesia is maintained with desflurane and remifentanil during thyroidectomy. Fifteen minutes before the end of surgery, infusion of remifentanil for surgery is discontinued. Then, dexmedetomidine has started infusion for 15 min (rate of 0.6 ug/kg/hr). Vital signs and complications of testing drugs are measured before and after infusion of testing drugs. Five minutes before the end of surgery, anesthetic gas (desflurane) is discontinued. After patient has awake, extubation has done. Extubation time and Recovery time,Cough reflex,Ramsay Sedation Scale, Visual analogue scale, and surgical outcomes such as postoperative bleeding, time to remove drainage and duration of hospital staying, postoperative complications are measured until POD#3.
- interventionNames
- Drug: Desflurane
- Drug: Remifentanil
- Procedure: Thyroidectomy
- Other: Vital signs
- Behavioral: Cough reflex
- Behavioral: Ramsay Sedation Scale
- Other: Extubation time and Recovery time
- Behavioral: Visual analogue scale
- Other: Postoperative bleeding
- Other: Postoperative complications
- Other: Time to remove drainage and duration of hospital staying
- Drug: Dexmedetomidine
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * Female patient, * Aged 20-60 yr, * ASA physical status 1-2, * Patients undergoing elective thyroidectomy under general anesthesia Exclusion Criteria: * Sighs of difficult airway, * History of respiratory disease or chronic cough, * Cardiovascular disease, * Pregnant or breast-feeding woman
References
Publications (4)
- BACKGROUNDPatel A, Davidson M, Tran MC, Quraishi H, Schoenberg C, Sant M, Lin A, Sun X. Dexmedetomidine infusion for analgesia and prevention of emergence agitation in children with obstructive sleep apnea syndrome undergoing tonsillectomy and adenoidectomy. Anesth Analg. 2010 Oct;111(4):1004-10. doi: 10.1213/ANE.0b013e3181ee82fa. Epub 2010 Aug 12. PMID 20705788
- BACKGROUNDReeve T, Thompson NW. Complications of thyroid surgery: how to avoid them, how to manage them, and observations on their possible effect on the whole patient. World J Surg. 2000 Aug;24(8):971-5. doi: 10.1007/s002680010160. PMID 10865043
- RESULTLee B, Lee JR, Na S. Targeting smooth emergence: the effect site concentration of remifentanil for preventing cough during emergence during propofol-remifentanil anaesthesia for thyroid surgery. Br J Anaesth. 2009 Jun;102(6):775-8. doi: 10.1093/bja/aep090. Epub 2009 May 2. PMID 19411668
- DERIVEDKim SH, Kim YS, Kim S, Jung KT. Dexmedetomidine decreased the post-thyroidectomy bleeding by reducing cough and emergence agitation - a randomized, double-blind, controlled study. BMC Anesthesiol. 2021 Apr 12;21(1):113. doi: 10.1186/s12871-021-01325-6. PMID 33845761