89Zr-J591 Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody in Patients With Glioblastoma Multiforme

Inclusion Criteria:

* Patient age \> 25 years old and \< 80 years old
* Patients with reoccurrence of brain tumor
* The principal investigator or co-PI must review MRI and CT findings based on the radiologic assessment provided they meet the following imaging criteria (as established in the clinical trial 09-177):

OR

* Patients with newly diagnosed GBM and one of the following options:
* Eligible for surgery after the last research scan.
* Significant residual disease after initial surgery
* The principal investigator or co-PI must review MRI and CT findings and agree with the presence of significant residual disease
* Treatment (non-surgical) naïve
* Karnofsky Performance Score ≥ 70

Exclusion Criteria:

* Laboratory values:

  * Serum creatinine \>2.5 mg/dL.
  * AST (SGOT) \>2.5x ULN.
  * Bilirubin (total) \>1.5x ULN.
  * Serum calcium \>11 mg/dL.
* Pregnant or breastfeeding (if a female is of childbearing potential, and unsure of pregnancy status, a standard pregnancy test should be done).
* If an initial biopsy demonstrates neoplasm other than GBM
* Presence of any other co-existing condition which, in the judgment of the investigator, might increase the risk to the subject.
* Presence of serious systemic illness, including: uncontrolled inter-current infection, uncontrolled malignancy, significant renal disease, or psychiatric/social situations, which might limit compliance with study requirements
* Prior treatment.
* Other serious illness (es), which might preclude completion of this, study or interfere with determination of causality of any adverse effects experienced in this study.