Clinical trial · Observational
Oxidative Damage and Antioxidant Mechanisms in COPD
Evaluation of Oxidative Damage and Antioxidant Mechanisms in COPD, Lung Cancer, and Obstructive Sleep Apnea Syndrome
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The environmental pollutants and endogenous reactive oxygen metabolites from inflammatory cells exert substantial pathological effects on the lung cells \[1\]. Oxidative stress (OS) is a major factor that plays a significant role in lung cancer (LC) \[2\], chronic obstructive pulmonary disease (COPD) \[3\] and obstructive sleep apnea syndrome (OSAS) \[4, 5\]. The current evidence suggests that OS takes part in the mechanisms involved in initiation, promotion and progression of respiratory diseases. The major exposures that cause OS can be summarized as smoking, and ambient air pollution that contains particulate matter smaller than aerodynamic diameter of 2.5 µm \[6-8\]. Epidemiological and clinical studies showed that the overall outcome of pulmonary OS is increased mortality due to increased incidence of respiratory diseases \[9\].
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Respiratory Diseases | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| oxidative and antioxidant biomarkers | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- OSAS
- description
- Obstructive sleep apnea syndrome
- interventionNames
- Genetic: oxidative and antioxidant biomarkers
- label
- COPD
- description
- Chronic obstructive pulmonary disease
- interventionNames
- Genetic: oxidative and antioxidant biomarkers
- label
- LC
- description
- Lung cancer
- interventionNames
- Genetic: oxidative and antioxidant biomarkers
- label
- HC
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 38 Years
- Maximum age
- 79 Years
Show eligibility criteria text
Inclusion Criteria: * Malondialdehyde (MDA), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OHdG), and coenzyme Q10 (CoQ10) levels were evaluated in the blood samples of patients with COPD, LC, and OSAS by high-pressure liquid chromatography method. Exclusion Criteria: * The diagnosis of lung cancer was based on the analysis of biopsy or cytologic specimens obtained by bronchoscopic examination, transthoracic biopsy or surgery. The patients Who hadn't have chemo or/and radiotherapy were included to the study. * The exclusion criteria for COPD, OSAS and lung cancer were the presence of the following: history of cardiovascular disease, hypertension, diabetes mellitus, inflammatory or infectious.
References
Publications (1)
- DERIVEDSunnetcioglu A, Alp HH, Sertogullarindan B, Balaharoglu R, Gunbatar H. Evaluation of Oxidative Damage and Antioxidant Mechanisms in COPD, Lung Cancer, and Obstructive Sleep Apnea Syndrome. Respir Care. 2016 Feb;61(2):205-11. doi: 10.4187/respcare.04209. Epub 2015 Nov 24. PMID 26604330