Clinical trial · Interventional
Infrahepatic Inferior Vena Cava Clamping Versus Selective Hepatic Vascular Exclusion Involving the Portal Triad Clamping
A Prospective Randomized Controlled Trial to Compare Infrahepatic Inferior Vena Cava Clamping With Selective Hepatic Vascular Exclusion Involving the Portal Triad Clamping in Hepatectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This clinical trial aims to compare infrahepatic inferior vena cava clamping (IIVCC) with selective hepatic vascular exclusion (SHVE) involving the portal triad clamping (PTC) in complex cirrhotic liver resection. One group will receive IIVCC plus PTC, while an another equivalent group patients will be operated using SHVE and PTC.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver Cirrhosis | — | UNRESOLVED | — |
| Liver Neoplasms | Liver Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Infrahepatic inferior vena cava clamping | Procedure | — | UNRESOLVED |
| Portal triad clamping | Procedure | — | UNRESOLVED |
| Selective hepatic vascular exclusion | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- IIVCC group
- description
- The portal triad and infrahepatic inferior vena cava are dissected and taped with a vessel loop, respectively. During liver parenchymal resection，portal triad and infrahepatic inferior vena cava clampings are performed at the specified transection depth from liver surface successively.
- interventionNames
- Procedure: Infrahepatic inferior vena cava clamping
- Procedure: Portal triad clamping
- type
- ACTIVE_COMPARATOR
- label
- SHVE group
- description
- In this group, the portal triad clamping and selective hepatic vascular exclusion of major hepatic veins are used. Different major hepatic veins are occluded by clamping forcep depending on the site of tumors. The clamping timepoints are same as the IIVCC group.
- interventionNames
- Procedure: Selective hepatic vascular exclusion
- Procedure: Portal triad clamping
Primary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. either male or female, older than 18 (include 18). 2. tumors oppress or be in close proximity to one or more of major hepatic veins. 3. the maximum diameter of tumor ≥ 5cm, number of lesions ≤ 3 and should be in same liver lobe if multiple lesions exit. 4. preoperative liver function assessment: Child-Pugh classification is A or B. 5. preoperative laboratory test: blood platlet count \> 100×10\^9/l, prothrombin activity \> 60%. 6. liver cirrhosis. Exclusion Criteria: 1. contraindication for surgery,e.g.severe disorders of circulation, respiratory or renal system. 2. extrahepatic metastasis in patients with malignancy or tumor invasion of portal vein, hepatic vein, bile duct or inferior vena cava. 3. hepatectomy accompanied with other organs resection(e.g. bile duct, intestine, pancreas or stomach) 4. regular hepatectomy. 5. tumors located in the left lateral lobe of liver. 6. previous hepatectomy. 7. pregnancy or lactation. 8. refusal to participate this trial.
References
Publications (0)
Data not yet available