Clinical trial · Interventional
Effect of Peritoneal Lavage With Clindamycin-Gentamicin Solution & Oncologic Outcome
Effect of Peritoneal Lavage With Clindamycin-Gentamicin Solution During Elective Colorectal Cancer Surgery on the Oncologic Outcome
NCT02399059CI-TRIAL-00017286completedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Antibiotic lavage reduces bacterial contamination and decreases SSI infection rate. SSI leads to an immunocompromised situation, leaving unattended the neoplasm. It has been described that SSI may result in a worse oncologic outcome.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Tumors | Colorectal Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Antibiotic lavage | Procedure | — | UNRESOLVED |
| Normal saline lavage | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Antibiotic lavage
- description
- Peritoneal irrigation with Gentamycin - clndamycin solution
- interventionNames
- Procedure: Antibiotic lavage
- type
- ACTIVE_COMPARATOR
- label
- Normal saline lavage
- description
- Peritoneal irrigation with normal saline
- interventionNames
- Procedure: Normal saline lavage
Primary outcomes (1)
- measure
- Global survival
- timeFrame
- 36 months after intervention
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * diagnosis of colon neoplasms * plans to undergo an elective surgery with curative aims Exclusion Criteria: * preoperative diagnosis of chronic renal failure (because of the risk of nephrotoxicity associated with intraperitoneal gentamicin absorption) * allergy to gentamicin or clindamycin.
References
Publications (0)
Data not yet available
No reference posted for this study.