Clinical trial · Interventional
Reading Disability in Children With NF1
Neuropsychological Characterisation of Cognitive Deficits Involved in Reading Disability in Children With NF1
NCT02397967CI-TRIAL-00017268completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A national, multicenter, randomized, transverse clinical trial, estimating the existence of phonological deficits in children with NF1 children compared with control children without NF1 with the same reading level.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Neurofibromatosis Type 1 | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Neuropsychological assessments | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Children NF1
- description
- Children diagnosed with NF1 according the NIH criteria Neuropsychological assessments
- interventionNames
- Other: Neuropsychological assessments
- type
- PLACEBO_COMPARATOR
- label
- Control group
- description
- Control group children without NF1 with the same reading level Neuropsychological assessments
- interventionNames
- Other: Neuropsychological assessments
Primary outcomes (1)
- measure
- Phonological deficits evaluated by the metaphonological capabilities including a subtraction test and phonemic Acronym test and memory capacity with phonological phonological memory test.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 8 Years
- Maximum age
- 12 Years
Show eligibility criteria text
Inclusion Criteria: * Age included between 8 and 12 years * Child presenting a type 1 neurofibromatosis according to 2 criteria in the following criteria list : * At least 6 café au lait spots * 2 or more neurofibromas or 1 plexiform neurofibroma * axillary or inguinal freckling * 1 optic nerf glioma * 2 or more Lisch nodules * 1 osseous lesion as sphenoid dysplasia or thinning of the long bone cortex with or without pseudoarthrosis * 1 A first degree relative (parent, sibling, or offspring) with NF1 by the above criteria * Membership in a national insurance * Consent of the child and the parents Exclusion Criteria: * Mental retardation (QI T \< 70) * Treated or untreated epilepsy * Visual deficit (visual Acuteness \< 4/10 * Presence of a symptomatic optic glioma * Presence of a brain tumor.
References
Publications (1)
- DERIVEDBiotteau M, Tournay E, Baudou E, Destarac S, Iannuzzi S, Faure-Marie N, Castelnau P, Schweitzer E, Rodriguez D, Kemlin I, Dorison N, Rivier F, Carneiro M, Preclaire E, Barbarot S, Lauwers-Cances V, Chaix Y. Reading Comprehension Impairment in Children With Neurofibromatosis Type 1 (NF1): The Need of Multimodal Assessment of Attention. J Child Neurol. 2021 Jul;36(8):625-634. doi: 10.1177/0883073820981270. Epub 2021 Jan 28. PMID 33507832