MT2014-25: Haplo NK With SQ IL-15 in Adult Relapsed or Refractory AML Patients

Inclusion Criteria (Recipient):

* Meets ONE of the following disease criteria:

  1. Primary AML induction failure: no CR after 2 or more induction attempts
  2. Relapsed AML or Secondary AML (from MDS or treatment related): not in CR after 1 or more cycles of standard re-induction therapy
  3. AML relapsed \> 2 months after transplant: No re-induction required, and no more than 1 re-induction cycle is allowed.
  4. Relapsed AML for patients \> 60 years of age the 1 cycle of standard chemotherapy is not required if either of the following criteria is met:

     * Relapse within 6 months of last chemotherapy
     * BM blast count \< 30% within 10 days of starting protocol therapy
* Available related HLA-haploidentical donor (aged 14 to 75 years) by at least Class I serologic typing at the A\&B locus
* Karnofsky Performance Status ≥ 60%
* Patients must have adequate organ within 14 days (28 days for pulmonary and cardiac) of study registration
* Able to be off prednisone or other immunosuppressive medications for at least 3 days prior to NK cell infusion (excluding preparative regimen pre-medications).
* Agrees to use contraception prior to study entry and for the duration of study participation.

Exclusion Criteria (Recipient):

* Bi-phenotypic acute leukemia.
* Transplant \< 60 days prior to study enrollment.
* Active autoimmune disease.
* History of severe asthma
* Uncontrolled intercurrent illness
* New or progressive pulmonary infiltrates on screening chest x-ray or chest CT scan that has not been evaluated with bronchoscopy
* Pleural effusion large enough to be detectable on chest x-ray.
* Pregnant women
* History of HIV, active or chronic hepatitis B, hepatitis C or HTLV-I infection
* Known hypersensitivity to any of the study agents used
* Received investigational drugs within the 14 days of study registration.
* Known active CNS involvement.

Criteria For Initial Donor Selection:

* Related donors (sibling, parent, offspring, parent or offspring of an HLA identical sibling).
* 14-75 years of age.
* At least 40 kilogram body weight.
* In general good health as determined by the evaluating medical provider.
* HLA-haploidentical donor/recipient match by at least Class I serologic typing at the A\&B locus.
* Not pregnant.
* Able and willing to undergo apheresis.