Clinical trial · Observational
Prospective, Observational, Real-world Oral Malignant Tumors Study
A Prospective, Observational, Real-world Study Based on the Register System of Oral and Maxillofacial Malignant Tumors
NCT02395367CI-TRIAL-00086897POROMScompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of the study is to construct a register system of oral and maxillofacial malignant tumors based on a prospective, observational, real-world study in north Chinese population.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Neoplasms | Head and Neck Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Postoperative Complications | — | UNRESOLVED | — |
| Quality of Life | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| adjuvant radiotherapy | Radiation | — | UNRESOLVED |
| neoadjuvant chemotherapy or adjuvant chemotherapy | Drug | — | UNRESOLVED |
| resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- disease-specific survival
- timeFrame
- 5 years
- description
- Disease-specific survival was calculated as the time from the first operation to the time of death or last follow-up; patients who died from causes other than oral and maxillofacial cancer were defined as survivors at the time of death.
Secondary outcomes (11)
- measure
- tumor recurrence
- timeFrame
- 5 years
- description
- Tumor recurrence was defined as local recurrence postoperatively.
- measure
- neck recurrence
- timeFrame
- 5 years
- description
- Neck recurrence was defined as regional recurrence whether was associated with local recurrence and distant metastasis or not.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * histological diagnosis of oral and maxillofacial malignant tumors * no previous treatment * a primary tumor without distant metastasis evidence * sites: lip, tongue, buccal mucosa, upper and lower gingiva, floor of the mouth, hard palate, oropharynx, salivary gland, upper and lower jaw, and maxillary sinus Exclusion Criteria: * patients decline to participate the study * refusal or inability to receive definitive treatment for the disease * recurrent tumors
References
Publications (4)
- DERIVEDZhang L, Liu C, Xu Q, Wang C, Li B, Liu H, Wang H, Feng Z. Preoperative Anxiety and Depression Symptoms Stratifying Based on Gender Differences Influence Outcome of Oral Squamous Cell Carcinoma. Head Neck. 2026 May;48(5):1165-1177. doi: 10.1002/hed.70105. Epub 2025 Nov 24. PMID 41287448
- DERIVEDXiong L, Yu H, Wei W, Wang C, Li B, Liu H, Cheng A, Li D, Han Z, Feng Z. Chemotherapy for primary cancer can reduce the risk of head and neck second primary malignancy: a propensity-matched analysis. Clin Oral Investig. 2023 Feb;27(2):571-580. doi: 10.1007/s00784-022-04752-y. Epub 2022 Oct 14. PMID 36239788
- DERIVEDZhu Y, Li B, Liu H, Li D, Cheng A, Wang C, Han Z, Feng Z. Prognostic factors and related complications/sequalae of squamous cell carcinoma located in the gingivobuccal complex. World J Surg Oncol. 2022 Jul 26;20(1):240. doi: 10.1186/s12957-022-02708-w. PMID 35883131
- DERIVEDMao MH, Wang S, Feng ZE, Li JZ, Li H, Qin LZ, Han ZX. Accuracy of magnetic resonance imaging in evaluating the depth of invasion of tongue cancer. A prospective cohort study. Oral Oncol. 2019 Apr;91:79-84. doi: 10.1016/j.oraloncology.2019.01.021. Epub 2019 Mar 4. PMID 30926067