Clinical trial · Observational
Roles of T Helper 1 Cytokines in Type 1 Diabetes
Roles of Interferon Gamma, Interleukin-2 and Tumor Necrotizan Factor Alpha in the Pathogenesis of Type 1 Diabetes
NCT02389335CI-TRIAL-00017155completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The mechanism of β cell destruction in Type 1 diabetes is not exactly known, Our hyphotesis is that interferon gamma, interleukin-2 and tumor necrotizan factor alpha have impotant roles in β cell destruction.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Type 1 Diabetes | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (4)
- label
- Group 1a
- description
- Patients with type 1 diabetes who have undetectable c-peptide ( ≤0.1 ng/mL) levels after mixed meal tolarance test: group 1a
- label
- Group 1b
- description
- Patients with type 1 diabetes who have c-peptide levels between 0.1-0.8 ng/mL after mixed meal tolerance test: group 1b
- label
- Group 1c
- description
- Patients with type 1 diabetes who have c-peptide levels ≥0.8ng/mL after mixed meal tolerance test: group 1c
- label
- Control
- description
- Healthy subjects
Primary outcomes (1)
- measure
- Roles of interferon gamma, interleukin-2, tumor necrotizan factor alpha in the pathogenesis of type 1 diabetes
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients giving consent to participate the study * Patients with type 1 diabetes according to WHO definiton Exclusion Criteria: * Acute and chronic inflammatory diseases, * significant concomitant diseases which may interfere with glucose metabolism * cancers, * hemoglobinopathies, * recently received antibiotics, * drugs influencing β-cell function and * insulin sensitivity or anti-inflammatory drugs * recent history of trauma
References
Publications (0)
Data not yet available
No reference posted for this study.