Clinical trial · Observational
Effect of Childhood Radioiodine Therapy on Salivary Function
NCT02375451CI-TRIAL-00028256completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hyperthyroidism | — | UNRESOLVED | — |
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
| Xerostomia | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Radioiodine | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Radioiodine
- description
- Patients with a history of childhood treatment with radioiodine will be assessed for symptoms of salivary function and measurement of saliva production. These data will be compared to a normal control group.
- interventionNames
- Other: Radioiodine
- label
- Control
- description
- Patients who are similar in age to those in the Radioiodine group, but who did not recieve I-131 therapy.
Primary outcomes (2)
- measure
- Salivary function (MST value)
- timeFrame
- 0 to 50 years after radioiodine treatment
- description
- sterile paper strip is used to measure saliva production (noninvasive testing)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 3 Years
- Maximum age
- 55 Years
Show eligibility criteria text
Inclusion Criteria: * Patients who have been treated with radioiodine therapy * Patients who have never received radioiodine therapy (negative control group) Exclusion Criteria: * Non-English speaking subjects will be excluded due to our lack of translation support resources at this time. Of note, participation in our study cannot benefit participants in any way.
References
Publications (0)
Data not yet available
No reference posted for this study.