Clinical trial · Interventional
Sensory Approach of Food Modifications Led by Chemotherapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of the present study was to evaluate the impact of chemotherapy on sensorial perception in lung cancer patients in comparison to a control group (individuals without lung cancer and chemotherapy treatment). We will use a longitudinal approach whereby 44 patients and 44 controls will be tested for olfactory and gustatory abilities before and after treatment (for patients) and for two sessions separated by the same duration for controls. Primary measure outcome will be to examine the impact of treatment on the perception of hedonic valence of odors. Secondary measure outcome will include odor and taste perceptual changes and questionnaires on eating habits and behaviors, in order to examine the impact of treatment on odor, taste and food perception.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Perform sensory tests | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Bronchial cancer
- description
- Patients with bronchial cancer will perform sensory tests before and after a 6-week period of chemotherapy.
- interventionNames
- Other: Perform sensory tests
- type
- PLACEBO_COMPARATOR
- label
- Control group
- description
- Healthy individuals will perform sensory tests before and after a 6-week period without chemotherapy.
- interventionNames
- Other: Perform sensory tests
Primary outcomes (1)
- measure
- Change in Pleasantness judgments in the European Test of Olfactory Capabilities (ETOC)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Men or women * Age ≥ 18 years old * People capable of giving their consent and of understanding the study * 18 ≤ BMI \< 30 kg/m² Control group: * controlled blood pressure * absence of pathology which can interfere with the criteria of the study (ENT, neurological, digestive,…) * absence of treatment which can interfere with the criteria of the study * absence of digestive disorders * women with contraception Patients: * Patients affected by a bronchial cancer (post-operative or metastatic) with small cells or not, that must be handled by a chemotherapy with salts of platinum (at least 3 cycles) * patients without previous chemotherapy * Absence of ENT or neurological pathologies Exclusion Criteria: \- Subjects having lost more than 10 % of their weight in the previous 2 months Patients: * Symptomatic intellectual and/or meningeal metastases * Mycosis of oral or superior digestive tract * Cancer of ENT or esophageal or gastric ways * Patients with digestive disorders (≥ rank 1) * Patients presenting a pathology which can interfere with the study
References
Publications (1)
- RESULTDrareni K, Dougkas A, Giboreau A, Laville M, Souquet PJ, Nazare JA, Fournel P, Bensafi M. Loss of smell in lung cancer patients undergoing chemotherapy: Prevalence and relationship with food habit changes. Lung Cancer. 2023 Mar;177:29-36. doi: 10.1016/j.lungcan.2023.01.007. Epub 2023 Jan 12. PMID 36701841