Clinical trial · Observational
Genetic, Neurophysiological and Psychological Risk Factors for Neuropathic Pain
Role of Genetic, Neurophysiological and Psychological Factors in the Development of Postsurgical Neuropathic Pain After Breast Surgery for Cancer
NCT02368275CI-TRIAL-00051554completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The objective of these cohorts is to detect potential genetic, neurophysiological psychological and cognitive risk factors for the development of chronic postsurgical pain including neuropathic pain.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- prospective cohort of patients undergoing mastectomy
- description
- Prospective cohort
- label
- cross sectional cohort of patients
- description
- Cross sectional cohort
Primary outcomes (1)
- measure
- neuropathic pain
- timeFrame
- 3, 6 and 12 months after surgery in the prospective cohort
- description
- neuropathic pain assessed with the DN4 questionnaire
Secondary outcomes (1)
- measure
- chronic postsurgical pain
- timeFrame
- 3, 6 and 12 months after surgery
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients undergoing surgery for breast cancer or thoracotomy for lung cancer followed during the course of the study or patients from the French cohort Seintinelle already operated from breast surgery over the past 2 years. Exclusion criteria : * Patients are not included if they have clinically significant or unstable psychiatric or somatic conditions (e.g. major depression, psychosis, uncontrolled diabetes mellitus or hypertension, neurological disorders, immune disease, body mass index \> 45), past or present substance abuse or any cognitive deterioration based on past medical history, semi-structured interview and lack of completion or full understanding of questionnaires. * Bilateral mastectomy (for women undergoing breast surgery) * Presence of pain before surgery
References
Publications (1)
- DERIVEDSperandio G, Baudic S, Bennedsgaard K, Grosen K, Andersen IS, Finnerup NB, Albi-Feldzer A, Flor H, Nees F, Bouhassira D, Attal N. Somatic and psychological predictors of chronic postsurgical pain in cancer patients: a machine learning approach in a longitudinal two-centre study. Br J Anaesth. 2026 Apr;136(4):1330-1340. doi: 10.1016/j.bja.2025.12.002. Epub 2026 Jan 7. PMID 41506969