Cannabics Capsules as Treatment to Improve Cancer Related CACS in Advanced Cancer Patients

Inclusion Criteria:

1. Age above 18 years
2. Histological evidence of an incurable malignancy
3. Estimated life expectancy ≥3 months
4. Performance status ≤2 (ECOG classification)
5. Self-report of weight loss of at least 3kg during the preceding 2 months and/or a dietitian-estimated caloric intake of less than 20 calories/kg of body weight per day
6. Patient believes that loss of appetite or loss of weight is an ongoing problem for him
7. Use of chemotherapy or radiotherapy is permitted
8. Sign of written informed consent

Exclusion Criteria:

1. Ongoing use of tube feedings or parental nutrition
2. Edema or ascites
3. Central nervous system metastases or brain tumors (patients with stable disease in the brain 28 days after treatment can be included in the study)
4. Treatment with adrenal corticosteroids (except for short-term dexamethasone during time of chemotherapy), androgens, progestational agents or other appetite stimulants within the previous two weeks
5. Insulin-requiring diabetes
6. Pregnancy or lactation or unwillingness to use oral contraceptives
7. Other life-threatening medical conditions
8. Anticipated alcohol or barbiturate use during the study period
9. Mechanical obstruction of the alimentary tract, malabsorption, or intractable vomiting
10. Use of cannabis or synthetic cannabinoids in the last four weeks