High-Flow Oxygen in Reducing Shortness of Breath Caused by Exercise in Patients With Cancer

Inclusion Criteria:

* Diagnosis of cancer, with evidence of primary or secondary lung involvement
* Average dyspnea Borg Scale \>= 4 of 10 with severe exertion over the past week
* Oxygen saturation \> 90% on ambient air at time of assessment
* Able to communicate in English or Spanish
* Karnofsky performance status \>= 50%
* Seen at Supportive Care, cardiopulmonary center, thoracic radiation oncology or thoracic medical oncology

Exclusion Criteria:

* Resting dyspnea modified Borg Scale \> 7 of 10 at enrollment
* Severe obstructive lung disease (forced expiratory volume in 1 second \[FEV1\]/forced vital capacity \[FVC\] \< 70% post bronchodilator and forced expiratory volume in 1 second \< 30% predicted)
* Delirium (i.e., Memorial Delirium Rating Scale \> 13)
* History of unstable angina or myocardial infarction in the last week
* Acute pulmonary embolus or pulmonary infarction in the last week
* Thrombosis of lower extremities in the last week
* Acute myocarditis, pericarditis, or endocarditis in the last week
* Symptomatic aortic stenosis or syncope in the last week
* Suspected dissecting aneurysm
* Severe untreated resting arterial hypertension (\> 200 mmHg systolic, \> 120 mmHg diastolic) at the time of enrollment
* Uncontrolled arrhythmias causing symptoms or hemodynamic compromise in the last week
* Uncontrolled heart failure in the last week
* Pleural effusion requiring thoracentesis within 1 week of study enrollment or scheduled during the study period
* Airway obstruction requiring stenting within 1 week of study enrollment or scheduled during the study period
* Pneumonia requiring antibiotics at the time of study enrollment