Bone Mineral Density Status in Pediatric and Adolescent Survivors of Childhood Cancer With History of Bone Fracture

Inclusion Criteria:

* History of childhood cancer
* Age ≥ 8 years and \< 20 years at time of enrollment
* ≥ 2 years since completion of cancer-directed therapy for first cancer
* Received chemotherapy for treatment of childhood cancer
* History of bone fracture after the conclusion of chemotherapy\*
* Not currently receiving cancer-directed therapy
* Signed written informed consent (by parent if patient is \< 18 years of age, or by patient, if he or she is ≥18 years of age)
* Patient assent for those ≥10 years of age and \< 18 years of age for whom a parent provides informed consent (\*History of bone fracture will be based on patient/parent report of fracture occurrence and will be confirmed in review of the medical record whenever feasible.)

Exclusion Criteria:

* Current treatment with bisphosphonates (as of time of enrollment)
* Current treatment with the anticonvulsant depakote (at time of enrollment)
* Currently pregnant