Clinical trial · Interventional
Phytoestrogens as an Alternative to Estradiol in Ovulation Induction in PCOS
Phytoestrogens as an Alternative to Estradiol in Reversing the Antiestrogenic Effect of Clomid on Endometrium in Ovulation Induction in Cases of Polycystic Ovarian Syndrome
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Prospective study conducted on 150 women with polycystic ovarian syndrome (PCOS) were randomly divided into 3 groups: group I (50 women) received clomiphene citrate (CC) only 50 mg orally every 8 hours started from cycle day 3 for 5 days, group II (50 women) received 2mg estradiol valerate daily from cycle day 7 - 11 in addition to CC and group III (50 women) received phytoestrogen (20mg of cimifuga racemosa from day 1- 12) in addition to CC.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovaries | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| clomiphene citrate | Drug | — | UNRESOLVED |
| estradiol valerate | Drug | — | UNRESOLVED |
| phytoestrogen | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- clomiphene citrate
- description
- only50 mg orally every 8 hours started from cycle day 3 for 5 days
- interventionNames
- Drug: clomiphene citrate
- type
- ACTIVE_COMPARATOR
- label
- estradiol valerate and CC
- description
- 2mg estradiol valerate orally daily from cycle day 7 - 11 in addition to CC
- interventionNames
- Drug: estradiol valerate
- Drug: clomiphene citrate
- type
- ACTIVE_COMPARATOR
- label
- Phytoestrogen and CC
- description
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 37 Years
Show eligibility criteria text
Inclusion Criteria: Women with both 1ry and 2ry infertility were included. All women were between 20 and 37 years old. Exclusion Criteria: women with endocrinological abnormalities as thyroid dysfunction or abnormal prolactin levels, those with hypothalamic or pituitary dysfunctions evaluated by low gonadotropin level, other causes of infertility as tubal factor evaluated by HSG or laparoscopy, abnormal uterine cavity evaluated by sonohystrography or hysteroscopy and male factor evaluated by semen analysis. Women with ovarian cysts were also excluded from the study
References
Publications (0)
Data not yet available