Treatment of Liver Metastases With Electrochemotherapy (ECTJ) Phase II

Inclusion Criteria:

1. Histologically and/or cytologically confirmed colorectal cancer.
2. Age over 18.
3. Life expectancy more than 3 month.
4. Performance status Karnofsky ≥ 70 or (World Health Organization) WHO ≤ 2.
5. Chemotherapy free interval 2-5 weeks, depending on the drugs used.
6. Patient must be mentally capable of understanding the information given.
7. Patient must give informed consent.
8. Patient must be discussed at the multidisciplinary team for tumors of the gastrointestinal tract before entering the trial.

Exclusion Criteria:

1. Secondary primary tumor, except surgically treated noninvasive cancer of cervix, or surgically or irradiated basal cell carcinoma
2. Visceral, bone or diffuse metastases.
3. Life-threatening infection and/or heart failure and/or liver failure and/or other severe systemic pathologies.
4. Clinically significant ascites.
5. Significant reduction in respiratory function.
6. Age less than 18 years.
7. Coagulation disturbances.
8. Cumulative dose of 250 mg/m2 bleomycin received.
9. Allergic reaction to bleomycin.
10. Impaired kidney function (creatinin \> 150 µmol/l).
11. Patients with epilepsy.
12. Patients with arrhythmias.
13. Patients with pacemaker or defibrillator.
14. Pregnancy.
15. Patient incapable of understanding the aim of the study or disagree with the entering into the clinical study.