Neuropharmacokinetics of Eribulin Mesylate in Treating Patients With Primary or Metastatic Brain Tumors

Inclusion Criteria:

* Patients must have a Karnofsky performance status of \>= 60
* Brain tumor patient is planning to undergo tumor resection or biopsy for the purpose of differentiating between tumor progression versus treatment-induced effects following radiation therapy and/or chemotherapy

  \* If a patient has magnetic resonance imaging (MRI) findings consistent with tumor but does not already have a histopathologic diagnosis of cancer, s/he may sign the consent form, but final eligibility for study enrollment will be determined based on results of the frozen section at time of surgery
* Patient may have received previous treatment for the brain tumor(s), including radiation (focal brain radiation, whole brain radiation or stereotactic radiosurgery), surgery or chemotherapy
* There is no limit to the number of prior chemotherapies
* Patients who have previously been treated with eribulin are allowed to participate in the microdialysis portion of the study only
* Absolute neutrophil count of \> 1500 cells/mm\^3
* Platelet count \> 100,000 cells/mm\^3
* Total bilirubin \< 2.0 mg/dl
* Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\]) \< 3 times the institutional upper limit of normal
* Alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) \< 3 times the institutional upper limit of normal
* Serum creatinine \< 1.5 x the institutional upper limit of normal
* All subjects must have the ability to understand and the willingness to sign a written informed consent
* Patients must have sufficiently recovered (=\< grade 1) from any toxicity of prior therapy; the required waiting period between the last dose of the most recent chemotherapy agent and the first dose of eribulin will be determined based on the half-life of the chemotherapy agent; the minimum time between stopping prior therapy and administering the first dose of eribulin should be 3.3 half-lives with the following exceptions: an interval of at least 6 weeks must elapse since treatment with a nitrosourea and at least 4 weeks since the last dose of bevacizumab
* If corticosteroids are required for controlling cerebral edema, patients must be on a stable dose of at least 1 week prior to enrollment
* Women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for 3 months following duration of study participation; women of child-bearing potential must have a negative serum pregnancy test prior to enrollment; should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately

Exclusion Criteria:

* Patients who are currently receiving chemotherapy, radiation therapy or are enrolled in another therapeutic clinical trial
* Patients who have not recovered from the toxicities of prior chemotherapy or radiation
* Patients who are taking any of the prohibited medications; if a patient is willing to discontinue such a medication in order to participate in the study, then there must be an appropriate washout period, based on the half-life of the particular drug, prior to the start of the study treatment
* Clinically evident congestive heart failure \> class II of the New York Heart Association (NYHA) guidelines, unstable angina or myocardial infarction within the previous 6 months
* Clinically significant cardiac arrhythmias, prolonged QT interval, congenital long QT syndrome
* Patients who cannot undergo brain magnetic resonance imaging (MRIs)
* Patients with existing grade 3 or 4 peripheral neuropathy
* Patients who have a serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol or may not be able to comply with the safety monitoring requirements of the study
* Female patients who are pregnant or breast-feeding
* Active, clinically significant serious infection requiring treatment with antibiotics, anti-virals or anti-fungals
* Non-compliance: subjects who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study