Clinical trial · Interventional
Nerveblocks for Persistent Pain After Breast Cancer Surgery
Tenderpoint and Ultrasound Guided Nerveblocks for Persistent Pain After Breast Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Persistent pain after breast cancer surgery (PPBCS) affects 25-60% of breast cancer survivors and nerve damage has been implicated as the cause of this neuropathic pain condition. Local anaesthetic blockade of tenderpoints and the intercostobrachial nerve (ICBN) could provide clues to pathophysiological mechanisms as well as aiding diagnosis and treatment of PPBCS but has never been attempted. The aims of this study is to examine clinical effect of ultrasound guided blockades of the ICBN and tenderpoints of pain.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Neuropathic Pain | — | UNRESOLVED | — |
| Pain | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bupivacaine | Drug | — | UNRESOLVED |
| NaCl | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- ICBN, active
- description
- Ultrasound guided injection of bupivacain, 10mL, 0.5% in proximity of the ICBN
- interventionNames
- Drug: Bupivacaine
- type
- PLACEBO_COMPARATOR
- label
- ICBN, placebo
- description
- Ultrasound guided injection of NaCl, 10mL in proximity of the ICBN
- interventionNames
- Drug: NaCl
- type
- EXPERIMENTAL
- label
- Tenderpoint, active
- description
- Ultrasound guided injection of bupivacain, 20mL, 0.25% in the tenderpoint
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * At least 1 year after surgery for breast cancer * Women aged 18 or over * Suffering from persistent pain in the breast, side of chest, axilla or arm (NRS 4 or over) Exclusion Criteria: * Previous cosmetic surgery * bilateral cancer * pregnant or lactating * other disease in the nervous system * in treatment for psychiatric disease * unable to understand Danish * unable to give informed concent
References
Publications (1)
- BACKGROUNDWijayasinghe N, Andersen KG, Kehlet H. Neural blockade for persistent pain after breast cancer surgery. Reg Anesth Pain Med. 2014 Jul-Aug;39(4):272-8. doi: 10.1097/AAP.0000000000000101. PMID 24918332