Clinical trial · Observational
Chronic Fatigue Following Acute Epstein-Barr Virus Infection in Adolescents
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Chronic fatigue syndrome (CFS) is characterized by unexplained, disabling and long lasting fatigue, as well as pain, impaired memory, sleep difficulties and other symptoms. Epstein-Barr virus (EBV) infection might precipitate CFS. In this study, 200 adolescents undergoing acute EBV infection will be followed prospectively, and also compared with a group of healthy controls. The aim is twofold: * To identify factors that predispose to chronic fatigue among adolescents with acute EBV infection * To compare pathophysiological features of patients with acute EBV infection with a group of healthy controls. Possible risk factors for chronic fatigue 6 months after EBV-infection includes: * Severity of the initial infection * Immune responses characteristics * Characteristics of the neuroendocrine stress response * Cognitive functioning * Emotional disturbances * Genetics/ epigenetics of candidate genes * Certain personality traits * Critical life events
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Epstein-Barr Virus Infections | — | UNRESOLVED | — |
| Fatigue Syndrome, Chronic | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Acute EBV infection
- label
- Healthy controls
Primary outcomes (2)
- measure
- Fatigue
- timeFrame
- 6 monhts
- description
- Chalder fatigue questionnaire, total score
- measure
- Steps per day
- timeFrame
- 6 monhts
- description
- Mean number of steps/day across 7 consecutive days, measured by accelerometer (ActivePal)
Secondary outcomes (8)
- measure
- Pain threshold
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 12 Years
- Maximum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 12 years and \< 20 years * Serological confirmation of acute EBV infection * Lives in one of the following Norwegian counties: Oslo, Akershus, Buskerud, Østfold, Vestfold Exclusion Criteria: * Medical treatment for another disease (hormonal conterception and antibiotics against tonsillitis/pharyngitis are accepted) * Pregnancy * Debut of illness \> 6 weeks ago
References
Publications (2)
- DERIVEDFevang B, Wyller VBB, Mollnes TE, Pedersen M, Asprusten TT, Michelsen A, Ueland T, Otterdal K. Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue. Front Immunol. 2021 Dec 20;12:715102. doi: 10.3389/fimmu.2021.715102. eCollection 2021. PMID 34987499
- DERIVEDPedersen M, Asprusten TT, Godang K, Leegaard TM, Osnes LT, Skovlund E, Tjade T, Oie MG, Wyller VBB. Predictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: A prospective cohort study. Brain Behav Immun. 2019 Jan;75:94-100. doi: 10.1016/j.bbi.2018.09.023. Epub 2018 Sep 25. PMID 30261303